产品货号:
Z21818
中文名称:
NPHS2抗体
英文名称:
Anti-NPHS2 Antibody
产品规格:
50μl|100μl|150μl
发货周期:
1~3天
产品价格:
询价
抗体名称 | Anti-NPHS2 Antibody |
指标别名 | NPHS2;PDCN;Podocin;SRN1 |
克隆性 | Polyclonal |
检验物种 | human,mouse,rat |
应用范围 | WB |
基因名称 | NPHS2 |
抗体来源 | Rabbit |
抗体类型 | IgG |
免疫原 | A synthetic peptide corresponding to a sequence in the middle region of human NPHS2(126-143aa CVKVVQEYERVIIFRLGH),different from the mouse sequence by one amino acid. |
实际分子量 | 42KD |
成分 | 500μg/mL antibody with PBS,0.02% NaN3,1mg BSA and 50% glycerol. |
纯化方式 | Immunogen affinity purified. |
浓度 | 500μg/mL |
产品形态 | 溶液 |
保存条件 | 12 months from date of receipt,-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
背景资料 | Podocin(PDCN) is a protein which lines the podocytes and assists in maintaining the barrier at the glomerular basement membrane.NPHS2 is a causative gene for Familial idiopathic nephrotic syndromes,which represents a heterogeneous group of kidney disorders,and include autosomal recessive steroid-resistant nephrotic syndrome,which is characterized by early childhood onset of proteinuria,rapid progression to end-stage renal disease and focal segmental glomerulosclerosis.By positional cloning,NPHS2 was mapped to 1q25-31.It is almost exclusively expressed in the podocytes of fetal and mature kidney glomeruli,and encodes a new integral membrane protein,podocin,belonging to the stomatin protein family.Boute et al.(2000) found ten different NPHS2 mutations,comprising nonsense,frameshift and missense mutations,to segregate with the disease,demonstrating a crucial role for podocin in the function of the glomerular filtration barrier. |
Uniprot ID | Q9NP85 |
推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1866) for IHC(P).*Blocking peptide可以联系我们购买。 |
基因名全称 | nephrosis 2,idiopathic,steroid-resistant(podocin) |
蛋白名全称 | Podocin |
推荐稀释比 | Western blot(WB) 1:500~2000 |
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