产品货号：
Z21568
中文名称：
Noggin/NOG抗体
英文名称：
Anti-Noggin/NOG Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-Noggin/NOG Antibody |
| 指标别名 | NOG;Noggin;SYM1;SYNS1 |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB,IHC,ELISA |
| 基因名称 | NOG |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | E.coli-derived human Noggin recombinant protein (Position:L43-T153). |
| 实际分子量 | 26KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | The secreted polypeptide,encoded by NOG gene,binds and inactivates members of the transforming growth factor-beta (TGF-beta) superfamily signaling proteins,such as bone morphogenetic protein-4 (BMP4).By diffusing through extracellular matrices more efficiently than members of the TGF-beta superfamily,this protein may have a principal role in creating morphogenic gradients.The protein appears to have pleiotropic effect,both early in development as well as in later stages.It was originally isolated from Xenopus based on its ability to restore normal dorsal-ventral body axis in embryos that had been artificially ventralized by UV treatment.The results of the mouse knockout of the ortholog suggest that it is involved in numerous developmental processes,such as neural tube fusion and joint formation.Recently,several dominant human NOG mutations in unrelated families with proximal symphalangism (SYM1) and multiple synostoses syndrome (SYNS1) were identified;both SYM1 and SYNS1 have multiple joint fusion as their principal feature,and map to the same region (17q22) as this gene.All of these mutations altered evolutionarily conserved amino acid residues.The amino acid sequence of this human gene is highly homologous to that of Xenopus,rat and mouse. |
| Uniprot ID | Q13253 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P).*Blocking peptide可以联系我们购买。 |
| 推荐稀释比 | Western blot(WB) 1:500～2000 (ELISA)： 1:100～1000 Immunohistochemistry in paraffin section (IHC) 1:100～500 |
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