产品货号：
Z21460
中文名称：
MYPT1/PPP1R12A抗体
英文名称：
Anti-MYPT1/PPP1R12A Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-MYPT1/PPP1R12A Antibody |
| 指标别名 | MBS;MYPT1;PPP1R12A |
| 克隆性 | Polyclonal |
| 检验物种 | human,monkey,mouse,rat |
| 应用范围 | WB,ICC/IF,FCM |
| 基因名称 | PPP1R12A |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthetic peptide corresponding to a sequence at the N-terminus of human PPP1R12A (1-17aa MKMADAKQKRNEQLKRW),identical to the related rat and mouse sequences. |
| 实际分子量 | 140KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | PPP1R12A(Protein phosphatase 1 regulatory subunit 12A),also called MYPT1(Myosin phosphatase target subunit 1),is an enzyme that in humans is encoded by the PPP1R12A gene.PPP1R12A is one of the subunits of myosin phosphatase.Sequencing analysis showed that human PPP1R12A contains 1,030 amino acids with a calculated molecular mass of approximately 115kD.The PPP1R12A gene is mapped on 12q21.2-q21.3.PPP1R12A is the protein that regulates PP1 function in smooth muscle relaxation.The cellular MYPT1-PP1-delta -specific inhibitor CPI17 caused a loss of merlin function characterized by merlin phosphorylation,Ras activation,and transformation.Jin et al.concluded that PPP1R12A and its substrate merlin are part of a previously undescribed tumor suppressor cascade that can be hindered in 2 ways,by mutation of the NF2 gene and by upregulation of the oncoprotein CPI17. |
| Uniprot ID | O14974 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P).*Blocking peptide可以联系我们购买。 |
| 基因名全称 | protein phosphatase 1,regulatory subunit 12A |
| 蛋白名全称 | Protein phosphatase 1 regulatory subunit 12A |
| 推荐稀释比 | Western blot(WB) 1:500～2000 Immunocytochemistry/Immunofluorescence(ICC/IF) 1:50～400 Flow cytometry (FCM) 1～3μg/1×106 cells |
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