产品货号：
Z21418
中文名称：
MT-CO1抗体
英文名称：
Anti-MT-CO1 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-MT-CO1 Antibody |
| 指标别名 | mitochondrially encoded cytochrome c oxidase;COI;MTCO1;COX1 |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB,IHC,ICC |
| 基因名称 | MT-CO1 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthetic peptide corresponding to a sequence at the C-terminus of human MTCO1(501-514aa PYHTFEEPVYMKS). |
| 实际分子量 | 37KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | Cytochrome c oxidase subunit I(CO1 or MTCO1) is 1 of 3 mitochondrial DNA(mtDNA) encoded subunits(MTCO1,MTCO2,MTCO3) of respiratory Complex IV.Complex IV is located within the mitochondrial inner membrane and is the third and final enzyme of the electron transport chain of mitochondrial oxidative phosphorylation.It is composed of 13 polypeptides.Subunits I,II,and III(MTCO1,MTCO2,MTCO3) are encoded by mtDNA while subunits IV,Va,Vb,VIa,VIb,VIc,VIIa,VIIb,VIIc,and VIII are nuclear encoded.The cytochrome c oxidase family of enzymes have 4 redox centers,2 hemes and 2 copper centers.In mitochondrial Complex IV,the 2 hemes are a and a3 and the 2 coppers are CuA and CuB.The 2 hemes and CuB are bound to subunit I.Acin-Perez et al.(2003) identified a cell line containing single and double missense mutations in the cytochrome c oxidase(COX) subunit I gene of mouse mitochondrial DNA.And they hypothesized that deleterious mutations can arise and become predominant;cultured cells can maintain several mtDNA haplotypes at stable frequencies;the respiratory chain has little spare COX capacity;and that the size of a cavity in the vicinity of val421 in MTCO1I of animal COX may affect the function of the enzyme. |
| Uniprot ID | P00395 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P).*Blocking peptide可以联系我们购买。 |
| 基因名全称 | mitochondrially encoded cytochrome c oxidase I |
| 蛋白名全称 | Cytochrome c oxidase subunit 1 |
| 推荐稀释比 | Western blot(WB) 1:500～2000 Immunohistochemistry in paraffin section (IHC) 1:50～400 Immunocytochemistry 1:50～400 (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user. |
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