产品货号：
Z20461
中文名称：
MDMX/MDM4抗体
英文名称：
Anti-MDMX/MDM4 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-MDMX/MDM4 Antibody |
| 指标别名 | Double minute 4 protein;HDMX;Mdm2 like p53 binding protein;MDM4;MDMX;MRP1;p53 binding protein Mdm4;Protein Mdm4;Protein Mdmx |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB,IHC |
| 基因名称 | MDM4 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthetic peptide corresponding to a sequence at the N-terminus of human MDMX (35-72aa KILHAAGAQGEMFTVKEVMHYLGQYIMVKQLYDQQEQH),different from the related mouse sequence by two amino acids,and from the related rat sequence by three amino acids. |
| 实际分子量 | 75KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | Protein Mdm4 is a protein that in humans is encoded by the MDM4 gene.This gene encodes a nuclear protein that contains a p53 binding domain at the N-terminus and a RING finger domain at the C-terminus,and shows structural similarity to p53-binding protein MDM2.Both proteins bind the p53 tumor suppressor protein and inhibit its activity,and have been shown to be overexpressed in a variety of human cancers.However,unlike MDM2 which degrades p53,this protein inhibits p53 by binding its transcriptional activation domain.This protein also interacts with MDM2 protein via the RING finger domain,and inhibits the latter's degradation.So this protein can reverse MDM2-targeted degradation of p53,while maintaining suppression of p53 transactivation and apoptotic functions.Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. |
| Uniprot ID | O15151 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P).*Blocking peptide可以联系我们购买。 |
| 基因名全称 | MDM4,p53 regulator |
| 蛋白名全称 | Protein Mdm4 |
| 推荐稀释比 | Western blot(WB) 1:500～2000 Immunohistochemistry in paraffin section (IHC) 1:50～400 (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user. |
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