产品货号:
Z20309
中文名称:
Klotho beta/KLB抗体
英文名称:
Anti-Klotho beta/KLB Antibody
产品规格:
100μl
发货周期:
1~3天
产品价格:
询价
抗体名称 | Anti-Klotho beta/KLB Antibody |
指标别名 | Beta-klotho;Betaklotho;BKL;KLB;Klotho beta |
克隆性 | Polyclonal |
检验物种 | human,mouse |
应用范围 | WB,ELISA |
基因名称 | KLB |
抗体来源 | Rabbit |
抗体类型 | IgG |
计算分子量 | 120KD |
成分 | Liquid form in PBS containing 50% glycerol,and 0.02% sodium azide. |
纯化方式 | KLOTB antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
浓度 | 1mg/mL |
产品形态 | 溶液 |
保存条件 | -20℃可保存1年,短期保存或频繁使用请置于4℃,可保存一个月,避免反复冻融。 |
背景资料 | Klotho beta,a divergent structural member of the glycosidase I superfamily,is expressed primarily in the liver and pancreas,with lower expression in adipose tissue.It is mapped to chromosome 4.The Klotho beta mediated interaction of human FGF19 (mouse FGF15) with FGF Receptor 4 in the liver negatively regulates bile acid synthesis by controlling the secretion of two key bile acid synthase genes,cholesterol 7-alpha hydroxylase (Cyp7a1) and sterol 12-alpha hydroxylase (Cyp8b1).Klotho beta is also an essential cofactor for FGF21 activity and the Klotho gene family may have evolved to confer tissue-specific bioactivity on FGF19 subfamily members. |
Uniprot ID | Q86Z14 |
基因名全称 | Beta-klotho |
蛋白名全称 | Beta-klotho |
推荐稀释比 | WB 1:500~2000 ELISA 1:5000~20000 |
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