产品货号：
Z20259
中文名称：
MBD4抗体
英文名称：
Anti-MBD4 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-MBD4 Antibody |
| 指标别名 | methyl-CpG binding domain 4;DNA glycosylase;MED1;MBD4 |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB |
| 基因名称 | MBD4 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthetic peptide corresponding to a sequence at the C-terminus of human MBD4(566-580aa YHDWLWENHEKLSLS),identical to the related rat and mouse sequences. |
| 实际分子量 | 66KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | MBD4(Methyl-CpG-Binding Domain Protein 4),also known as MED1,is a protein that in humans is encoded by the MBD4 gene.MBD4 specifically binds methylated DNA,colocalizes with methylated sequences,and is likely to mediate the effects of DNA methylation in mammalian cells(Hendrich and Bird,1998).Riccio et al.(1999) mapped the MBD4 gene to chromosome 3q21-q22 by FISH.Hendrich and Bird(1998) found that both MBD2 and MBD4 specifically bound methylated DNA in vitro and colocalized with methylated sequences in vivo.They concluded that MBD2 and MBD4 are likely to be mediators of the effects of DNA methylation in mammalian cells.Hendrich et al.(1999) showed that MBD4 contains a methyl-CpG-binding domain that can efficiently remove thymine or uracil from mismatched CpG sites in vitro.Furthermore,the methyl-CpG-binding domain of MBD4 binds preferentially to 5-methylcytosine CpG-TpG mismatches--the primary product of deamination at methyl-CpG. |
| Uniprot ID | O95243 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P).*Blocking peptide可以联系我们购买。 |
| 基因名全称 | methyl-CpG binding domain protein 4 |
| 蛋白名全称 | Methyl-CpG-binding domain protein 4 |
| 推荐稀释比 | Western blot(WB) 1:500～2000 |
相关搜索：MBD4抗体，MBD4多抗，Anti-MBD4 Antibody