产品货号：
Z20178
中文名称：
MAP3K1抗体
英文名称：
Anti-MAP3K1 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-MAP3K1 Antibody |
| 指标别名 | MAP3K1;MAPK/ERK kinase kinase 1;MAPKKK1;MEK kinase 1;MEKK;MEKK 1;MEKK1 |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | IHC,WB |
| 基因名称 | MAP3K1 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthetic peptide corresponding to a sequence at the C-terminus of human MEKK1(1418-1432aa PEVLRGQQYGRSCDV),identical to the related rat and mouse sequences. |
| 实际分子量 | 130KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | MAP3K1(Mitogen-activated protein kinase kinase kinase 1),also known as MEKK1,MAPKKK1,MEK KINASE or MAP/ERK KINASE KINASE 1,is an enzyme that in humans is encoded by the MAP3K1 gene.Vinik et al.(1995) identified DNA sequence and size polymorphisms in intronic and 3-prime untranslated regions of the mouse Map3k1 gene and the human MAP3K1 homolog.Using these allele-specific polymorphisms,they mapped the Map3k1 gene in an intersubspecific backcross to mouse chromosome 13.They mapped the human MAP3K1 gene to chromosome 5 by somatic cell hybrid analysis.By assaying transfected COS-1 cells,Xia et al.(1998) showed that human MEKK1 activated JNK1(MAPK8) robustly and p38-alpha(MAPK14) less efficiently,but it had only a marginal effect on ERK2(MAPK1).MEKK1 directly and specifically interacted with JNKK1(MAP2K4) and activated JNKK1 in cells and in vitro.Phosphorylation of JNKK1 by MEKK1 disrupted their interaction.MEKK1 and JNK1 competed for binding to JNKK1.Xia et al.(1998) concluded that JNKK1 is the preferred MEKK1 substrate. |
| Uniprot ID | Q13233 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P).*Blocking peptide可以联系我们购买。 |
| 基因名全称 | mitogen-activated protein kinase kinase kinase 1,E3 ubiquitin protein ligase |
| 蛋白名全称 | Mitogen-activated protein kinase kinase kinase 1 |
| 推荐稀释比 | Western blot(WB) 1:500～2000 Immunohistochemistry in paraffin section (IHC) 1:50～400 (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user. |
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