产品货号：
Z19976
中文名称：
LRRC51/LRTOMT抗体
英文名称：
Anti-LRRC51/LRTOMT Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-LRRC51/LRTOMT Antibody |
| 指标别名 | leucine rich transmembrane and O-methyltransferase domain containing;CFAP111;DFNB63;LRRC51;LRTOMT |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB,IHC |
| 基因名称 | LRTOMT |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthetic peptide corresponding to a sequence of human LRTOMT (RLLTVERDPRTAAVAEKLIRLAGFDEHMVEL). |
| 实际分子量 | 28KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | Leucine rich transmembrane and O-methyltransferase domain containing is a protein that in humans is encoded by the LRTOMT gene.It is mapped to 11q13.4.This gene has evolved in primates as a fusion of two ancestral neighboring genes,Lrrc51 and Tomt,which exist as two independent genes in rodents.The fusion gene contains some shared exons,but encodes structurally unrelated proteins,LRTOMT1 and LRTOMT2.Those variants that utilize the more centromere-proximal 3' terminal exon (short transcript form) encode LRTOMT1,while those variants that use a more centromere-distal 3' terminal exon (long transcript form) encode the LRTOMT2 protein.There is a small region within one of the exons of this gene that contains overlapping alternate reading frames for both LRTOMT1 and LRTOMT2.LRTOMT1 shares similarity with the protein encoded by mouse Lrrc51,while LRTOMT2 shares similarity with the protein encoded by mouse Tomt.Alternative splicing results in multiple transcript variants,encoding different isoforms of both LRTOMT1 and LRTOMT2.The LRTOMT1 protein is a leucine-rich repeat-containing protein,while the LRTOMT2 protein is a catechol-O-methyltransferase that catalyzes the transfer of a methyl group from S-adenosyl-L-methionine to a hydroxyl group of catechols and is essential for auditory and vestibular function.Mutations in this gene have been associated with nonsyndromic deafness. |
| Uniprot ID | Q8WZ04 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P).*Blocking peptide可以联系我们购买。 |
| 推荐稀释比 | Western blot(WB) 1:500～2000 Immunohistochemistry in paraffin section (IHC) 1:50～400 (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user. |
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