产品货号：
Z19759
中文名称：
LKB1/STK11 (Phospho-Ser428)抗体
英文名称：
Anti-LKB1/STK11 (Phospho-Ser428) Antibody
产品规格：
50μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-LKB1/STK11 (Phospho-Ser428) Antibody |
| 指标别名 | LKB1;PJS;serine/threonine kinase 11;STK11;STK11/LKB1 |
| 克隆性 | Polyclonal |
| 检验物种 | human |
| 应用范围 | WB |
| 基因名称 | STK11 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | This Phospho-LKB1 (Ser428) antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 388-429 amino acids from the human LKB1 (Ser428). |
| 计算分子量 | 49kDa |
| 成分 | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. |
| 纯化方式 | This antibody is purified through a protein A column,followed by peptide affinity purification |
| 保存条件 | Maintain refrigerated at 2～8℃ for up to 2 weeks.For long term storage,store at -20℃ in small aliquots to prevent freeze-thaw cycles. |
| 背景资料 | Tumor suppressor serine/threonine-protein kinase that controls the activity of AMP-activated protein kinase (AMPK) family members,thereby playing a role in various processes such as cell metabolism,cell polarity,apoptosis and DNA damage response.Acts by phosphorylating the T-loop of AMPK family proteins,thus promoting their activity:phosphorylates PRKAA1,PRKAA2,BRSK1,BRSK2,MARK1,MARK2,MARK3,MARK4,NUAK1,NUAK2,SIK1,SIK2,SIK3 and SNRK but not MELK.Also phosphorylates non- AMPK family proteins such as STRADA,PTEN and possibly p53/TP53.Acts as a key upstream regulator of AMPK by mediating phosphorylation and activation of AMPK catalytic subunits PRKAA1 and PRKAA2 and thereby regulates processes including:inhibition of signaling pathways that promote cell growth and proliferation when energy levels are low,glucose homeostasis in liver,activation of autophagy when cells undergo nutrient deprivation,and B-cell differentiation in the germinal center in response to DNA damage.Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton.Required for cortical neuron polarization by mediating phosphorylation and activation of BRSK1 and BRSK2,leading to axon initiation and specification.Involved in DNA damage response:interacts with p53/TP53 and recruited to the CDKN1A/WAF1 promoter to participate in transcription activation.Able to phosphorylate p53/TP53;the relevance of such result in vivo is however unclear and phosphorylation may be indirect and mediated by downstream STK11/LKB1 kinase NUAK1.Also acts as a mediator of p53/TP53-dependent apoptosis via interaction with p53/TP53:translocates to the mitochondrion during apoptosis and regulates p53/TP53-dependent apoptosis pathways.In vein endothelial cells,inhibits PI3K/Akt signaling activity and thus induces apoptosis in response to the oxidant peroxynitrite (in vitro).Regulates UV radiation-induced DNA damage response mediated by CDKN1A.In association with NUAK1,phosphorylates CDKN1A in response to UV radiation and contributes to its degradation which is necessary for optimal DNA repair (PubMed:25329316). |
| Uniprot ID | Q15831 |
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