产品货号：
Z19242
中文名称：
KEAP1抗体
英文名称：
Anti-KEAP1 Antibody
产品规格：
0.1mg
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-KEAP1 Antibody |
| 指标别名 | Cytosolic inhibitor of Nrf2;INrf2;KEAP1;Kelch like protein 19;KIAA0132;KLHL19 |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | ELISA,WB,IF |
| 基因名称 | KEAP1 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | Anti-KEAP1 antibody was raised against a 19 amino acid synthetic peptide near the carboxy terminus of human KEAP1.The immunogen is located within the last 50 amino acids of KEAP1. |
| 计算分子量 | 70kDa |
| 成分 | KEAP1 Antibody is supplied in PBS containing 0.02% sodium azide. |
| 纯化方式 | KEAP1 Antibody is affinity chromatography purified via peptide column. |
| 浓度 | 1mg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 4℃可保存3个月，-20℃可保存1年。 |
| 背景资料 | KEAP1 (kelch-like ECH-associated protein 1) is a stress sensing adaptor for the Cullin3 (Cul3)-dependent E3 ubiquitin ligase complex that negatively regulates NRF2 (NF-E2-related factor 2) and plays a role in the oxidative stress response.It targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome.KEAP1 contains an amino terminal BTB/POZ domain and a carboxyl terminal KELCH domain which are required for interaction with NRF2,and in binding Cul3-E3 ubiquitin ligase.Altered expression of NRF2 is associated with chronic obstructive pulmonary disease (COPD).KEAP1 also targets the down regulation of NF-百B activity by targeting IKK汕degradation.Mutation of the KEAP1 gene is found in lung cancer. |
| Uniprot ID | Q14145 |
| 基因名全称 | Kelch-like ECH-associated protein 1 |
| 蛋白名全称 | Kelch-like ECH-associated protein 1 |
| 推荐稀释比 | WB:1～2μg/mL;IF:20μg/mL.Antibody validated:Western Blot in human,mouse and rat samples;Immunofluorescence in human samples.All other applications and species not yet tested. |
相关搜索：KEAP1抗体，KEAP1多抗，Anti-KEAP1 Antibody