产品货号：
Z19178
中文名称：
IRF3抗体
英文名称：
Anti-IRF3 Antibody (N-Term)
产品规格：
50μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-IRF3 Antibody (N-Term) |
| 指标别名 | interferon regulatory factor 3,IRF 3,IRF3 |
| 克隆性 | Polyclonal |
| 检验物种 | human |
| 应用范围 | WB |
| 基因名称 | IRF3 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | This IRF3 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 78-108 amino acids from human IRF3. |
| 计算分子量 | 47kDa |
| 成分 | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. |
| 纯化方式 | This antibody is purified through a protein A column,followed by peptide affinity purification |
| 保存条件 | Maintain refrigerated at 2～8℃ for up to 2 weeks.For long term storage,store at -20℃ in small aliquots to prevent freeze-thaw cycles. |
| 背景资料 | Key transcriptional regulator of type I interferon (IFN)-dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses.Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters.Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction.Found in an inactive form in the cytoplasm of uninfected cells and following viral infection,double-stranded RNA (dsRNA),or toll-like receptor (TLR) signaling,is phosphorylated by IKBKE and TBK1 kinases.This induces a conformational change,leading to its dimerization and nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1),a complex which activates the transcription of the type I IFN and ISG genes.Can activate distinct gene expression programs in macrophages and can induce significant apoptosis in primary macrophages. |
| Uniprot ID | Q14653 |
相关搜索：IRF3抗体，IRF3(N-Term)多抗，Anti-IRF3 Antibody (N-Term)