产品货号：
Z19166
中文名称：
IRF3抗体
英文名称：
Anti-IRF3 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-IRF3 Antibody |
| 指标别名 | interferon regulatory factor 3;IRF 3;IRF3 |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse |
| 应用范围 | WB,ICC/IF,FCM,IHC,ELISA |
| 基因名称 | IRF3 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | E.coli-derived human IRF3 recombinant protein (Position:M1-S427). |
| 实际分子量 | 50～55KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | IRF3(interferon regulatory factor 3)?is a member of the interferon regulatory transcription factor(IRF) family.The IRF3 gene is mapped on 19q13.33.IRF3 is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with?CREBBP.IRF3 plays an important role in the?innate immune system's response to?viral infection.Aggregated?MAVS?have been found to activate IRF3 dimerization.Although?IRF3?increased transcriptional activity from an ISRE-containing promoter,expression of?IRF3?as a Gal4 fusion protein did not activate expression of a chloramphenicol acetyltransferase(CAT) reporter gene containing repeats of the Gal4-binding sites.?Translocation of?IRF3?was accompanied by an increase in serine and threonine phosphorylation.?The transcriptional activators CREBBP and EP300 coimmunoprecipitated with?IRF3?only subsequent to viral infection,and the authors stated that these are also subunits of DRAF1. |
| Uniprot ID | Q14653 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot. |
| 基因名全称 | interferon regulatory factor 3 |
| 蛋白名全称 | Interferon regulatory factor 3 |
| 推荐稀释比 | Western blot (WB) 1:500～2000 Immunohistochemistry (IHC) 1:50～400 Immunocytochemistry/Immunofluorescence (ICC/IF) 1:50～400 Flow cytometry (FCM) 1～3μg/1×106 cells Enzyme linked immunosorbent assay (ELISA) 1:100～1000 (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user. |
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