产品货号：
Z19090
中文名称：
LARP1抗体
英文名称：
Anti-LARP1 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-LARP1 Antibody |
| 指标别名 | KIAA0731;La related protein 1;LARP;LARP1 |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse |
| 应用范围 | WB,IHC,ICC/IF,FCM(Intracellular),ELISA |
| 基因名称 | LARP1 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | E.coli-derived human LARP1 recombinant protein (Position:K123-E401). |
| 实际分子量 | 150KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | La-related protein 1 (LARP1) is a 150kDa protein that in humans is encoded by the LARP1 gene.La-related protein 1 (LARP1) is a ubiquitously expressed RNA binding protein that promotes both global and specific mRNA translation in cells.LARP1 belongs to the La-related protein family and contains two RNA binding domains,a La motif (LAM),and a neighboring RNA recognition motif-like (RRM-L) domain.Research studies indicate that LARP1 acts downstream of mTORC1 to facilitate cell proliferation and growth by promoting global mRNA translation and translation of mRNAs containing a 5'Terminal Oligo-Pyrimidine (5'TOP) motif,which code for translational machinery components.At the molecular level,LARP1 associates with 5'TOP mRNAs and multiple translation machinery components to positively regulate translation.Additional studies show that LARP1 expression is upregulated in hepatocellular carcinoma (HCC) patients and that high LARP1 expression in HCC negatively correlates with survival rate. |
| Uniprot ID | Q6PKG0 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot. |
| 基因名全称 | La ribonucleoprotein 1,translational regulator |
| 蛋白名全称 | La-related protein 1 |
| 推荐稀释比 | Western blot (WB) 1:500～2000 Immunohistochemistry (IHC) 1:50～400 Immunocytochemistry/Immunofluorescence (ICC/IF) 1:50～400 Flow Cytometry(Intracellular) 1～3μg/1×106 cells Enzyme linked immunosorbent assay (ELISA) 1:100～1000 (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user. |
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