产品货号：
Z18788
中文名称：
Integrin Beta 4/ITGB4抗体
英文名称：
Anti-Integrin Beta 4/ITGB4 Antibody
产品规格：
100μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-Integrin Beta 4/ITGB4 Antibody |
| 指标别名 | CD104;GP150;Integrin beta 4;integrin;beta 4;ITGB4 |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB,IHC,ELISA |
| 基因名称 | ITGB4 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | Synthesized peptide derived from human Integrin beta4 around the non-phosphorylation site of Y1510. |
| 计算分子量 | 202KD |
| 成分 | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| 纯化方式 | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| 浓度 | 1mg/mL |
| 产品形态 | 溶液 |
| 保存条件 | -20℃可保存1年，短期保存或频繁使用请置于4℃，可保存一个月，避免反复冻融。 |
| 背景资料 | ITGB4(Integrin,beta-4),also known as CD104 (Cluster of Differentiation 104),is a human gene.The gene encodes the integrin beta 4 subunits,a receptor for the laminins.This subunit tends to associate with alpha 6 subunits and is likely to play a pivotal role in the biology of invasive carcinoma.The ITGB4 gene is mapped on 17q25.1.Using expression profiling,Yang et al.found that ITGB4 was upregulated 6-fold by ZKSCAN3 in transfected human colon cancer cells compared with parental cells.They confirmed that ZKSCAN3 bound the promoter of ITGB4 in vitro and in vivo.ITGB4 knockdown by short hairpin RNA countered ZKSCAN3-augmented anchorage-independent colony formation in the colon cancer cell lines.The integrin beta-4 subunit is characterized by an unusually long cytoplasmic domain that harbors 4 fibronectin type III (FNIII) repeats,residing in 2 pairs separated by a connecting segment.Vidal et al.found compound heterozygosity for mutations in the ITGB4 gene in an infant with junctional epidermolysis bullosa associated with pyloric atresia. |
| Uniprot ID | P16144 |
| 基因名全称 | Integrin beta-4 |
| 蛋白名全称 | Integrin beta-4 |
| 推荐稀释比 | WB 1:500～1:2000 IHC 1:100～1:300 ELISA 1:20000 |
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