产品货号：
Z18672
中文名称：
HUWE1抗体
英文名称：
Anti-HUWE1 Antibody
产品规格：
0.1mg
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-HUWE1 Antibody |
| 指标别名 | ARF binding protein 1,ARF BP1,HECTH9,HSPC272,HUWE1,Ib772,KIAA0312,KIAA1578,Large structure of UREB1,LASU1,Mcl 1 ubiquitin ligase E3,MULE,URE B1,URE binding protein 1,UREB1 |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | ELISA,WB,ICC,IF |
| 基因名称 | HUWE1 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | ARF-BP1 antibody was raised against a 19 amino acid synthetic peptide from near the carboxy terminus of human ARF-BP1.The immunogen is located within amino acids 4250 - 4300 of ARF-BP1. |
| 计算分子量 | 482kDa |
| 成分 | ARF-BP1 Antibody is supplied in PBS containing 0.02% sodium azide. |
| 纯化方式 | ARF-BP1 Antibody is affinity chromatography purified via peptide column. |
| 浓度 | 1mg/mL |
| 产品形态 | 溶液 |
| 保存条件 | ARF-BP1 antibody can be stored at 4℃ up to one year.Antibodies should not be exposed to prolonged high temperatures. |
| 背景资料 | The ARF tumor suppressor is a critical regulator of p53 stability.In addition to p53,ARF1 binds to other proteins such as MDM2 and ARF-BP1,a large protein containing HECT,UBA and WWE motifs.ARF-BP1 directly binds and ubiquitinates p53;this activity is inhibited by ARF,indicating that ARF-BP1 is a critical mediator of the p53-dependent and p53-independent tumor suppressor functions of ARF.ARF-BP1 can also catalyze the polyubiquitination of Mcl-1,an anti-apoptotic Bcl-2 family member involved in DNA damage-induced apoptosis.Elimination of ARF-BP1 expression by RNA interference stabilized Mcl-1 protein,resulting in an attenuation of apoptosis induced by DNA-damage agents. |
| Uniprot ID | Q7Z6Z7 |
| 基因名全称 | HECT,UBA and WWE domain containing 1 |
| 蛋白名全称 | HECT,UBA and WWE domain containing 1 |
| 推荐稀释比 | ARF-BP1 antibody can be used for detection of ARF-BP1 by Western blot at 1μg/mL.Antibody can also be used for immunocytochemistry starting at 5μg/mL.For immunofluorescence start at 20μg/mL.Antibody validated:Western Blot in human samples;Immunocytochemistry in human samples and Immunofluorescence in human samples.All other applications and species not yet tested. |
相关搜索：HUWE1抗体，HUWE1多抗，Anti-HUWE1 Antibody