产品货号：
Z18501
中文名称：
HSD11B2抗体
英文名称：
Anti-HSD11B2 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-HSD11B2 Antibody |
| 指标别名 | 11 beta HSD2;11 DH2;AME;AME1;HSD11B2;HSD11K;HSD2;SDR9C3 |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB,IHC,IHC-F,IF |
| 基因名称 | HSD11B2 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthetic peptide corresponding to a sequence at the C-terminus of human HSD11B2 (277-309aa EKRKQLLLANLPQELLQAYGKDYIEHLHGQFLH),different from the related mouse sequence by five amino acids,and from the related rat sequence by three amino acids. |
| 实际分子量 | 43KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | Corticosteroid 11-β-dehydrogenase isozyme 2,also known as 11-β-hydroxysteroid dehydrogenase 2,is an enzyme that in humans is encoded by the HSD11B2 gene.There are at least two isozymes of the corticosteroid 11-beta-dehydrogenase,a microsomal enzyme complex responsible for the interconversion of cortisol and cortisone.The type I isozyme has both 11-beta-dehydrogenase (cortisol to cortisone) and 11-oxoreductase (cortisone to cortisol) activities.The type II isozyme,encoded by this gene,has only 11-beta-dehydrogenase activity.In aldosterone-selective epithelial tissues such as the kidney,the type II isozyme catalyzes the glucocorticoid cortisol to the inactive metabolite cortisone,thus preventing illicit activation of the mineralocorticoid receptor.In tissues that do not express the mineralocorticoid receptor,such as the placenta and testis,it protects cells from the growth-inhibiting and/or pro-apoptotic effects of cortisol,particularly during embryonic development.Mutations in this gene cause the syndrome of apparent mineralocorticoid excess and hypertension. |
| Uniprot ID | P80365 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P).*Blocking peptide可以联系我们购买。 |
| 基因名全称 | hydroxysteroid (11-beta) dehydrogenase 2 |
| 蛋白名全称 | Corticosteroid 11-beta-dehydrogenase isozyme 2 |
| 推荐稀释比 | Western blot (WB) 1:500～2000 Immunohistochemistry in paraffin section (IHC) 1:50～400 Immunohistochemistry in frozen section (IHC-F) 1:50～400 Immunofluorescence (IF) 1:50～400 (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user. |
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