产品货号：
Z18289
中文名称：
IL-17/IL17A抗体
英文名称：
Anti-IL-17/IL17A Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-IL-17/IL17A Antibody |
| 指标别名 | CTLA 8;CTLA8;IL 17;IL 17A;IL17;IL-17;IL17A;interleukin 17A |
| 克隆性 | Polyclonal |
| 检验物种 | human |
| 应用范围 | IHC |
| 基因名称 | IL17A |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthetic peptide corresponding to a sequence of human IL17A (EDPERYPSVIWEAKCRH). |
| 成分 | 500μg/mL antibody with PBS,0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | Interleukin-17A is a protein that in humans is encoded by the IL17A gene.This gene is a member of the IL-17 receptor family which includes five members (IL-17RA-E) and the encoded protein is a proinflammatory cytokine produced by activated T cells.IL-17A-mediated downstream pathways induce the production of inflammatory molecules,chemokines,antimicrobial peptides,and remodeling proteins.The encoded protein elicits crucial impacts on host defense,cell trafficking,immune modulation,and tissue repair,with a key role in the induction of innate immune defenses.This cytokine stimulates non-hematopoietic cells and promotes chemokine production thereby attracting myeloid cells to inflammatory sites.This cytokine also regulates the activities of NF-kappaB and mitogen-activated protein kinases and can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2),as well as enhance the production of nitric oxide (NO).IL-17A plays a pivotal role in various infectious diseases,inflammatory and autoimmune disorders,and cancer.High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis,psoriasis and multiple sclerosis.The lung damage induced by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is to a large extent,a result of the inflammatory response promoted by cytokines such as IL17A |
| Uniprot ID | Q16552 |
| 推荐配套试剂 | Biorab recommends HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P). |
| 基因名全称 | interleukin 17A |
| 蛋白名全称 | Interleukin-17A |
| 推荐稀释比 | Immunohistochemistry in paraffin section (IHC) 1:50～400 (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user. |
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