产品货号：
Z18143
中文名称：
HEXA抗体
英文名称：
Anti-HEXA Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-HEXA Antibody |
| 指标别名 | HEXA;Hexosaminidase subunit A;TSD |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB,ICC/IF,ELISA |
| 基因名称 | HEXA |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | E.coli-derived human HEXA recombinant protein (Position:A135-H179). |
| 实际分子量 | precursor61KD,mature54KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | HEXA,hexosaminidase A (alpha polypeptide),is an enzyme that in humans is encoded by the HEXA gene.Hexosaminidase A and the cofactor GM2 activator protein catalyze the degradation of the GM2 gangliosides and other molecules containing terminal N-acetyl hexosamines.The HEXA gene encodes the alpha subunit of hexosaminidase A,a lysosomal enzyme involved in the breakdown of gangliosides.The HEXA gene is mapped on 15q23.Even though the alpha and beta subunits of hexosaminidase A can both cleave GalNAc residues,only the alpha subunit is able to hydrolyze GM2 gangliosides.The alpha subunit contains a key residue,Arg-424,which is essential for binding the N-acetyl-neuramanic residue of GM2 gangliosides.Chimeric constructs were expressed in HeLa cells and selected constructs were produced in the baculovirus expression system to determine their ability to degrade GM2 ganglioside in the presence of GM2 activator protein.Their results allowed them to define 2 noncontiguous sequences in the alpha subunit (amino acids 1-191 and 403-529) which,when substituted into analogous positions in the beta subunit,conferred activity against the sulfated substrate. |
| Uniprot ID | P06865 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot. |
| 基因名全称 | hexosaminidase subunit alpha |
| 蛋白名全称 | Beta-hexosaminidase subunit alpha |
| 推荐稀释比 | Western blot(WB) 1:500～2000 Immunocytochemistry/Immunofluorescence (ICC/IF) 1:50～400 ELISA 1:100～1000 |
相关搜索：HEXA抗体，HEXA多抗，Anti-HEXA Antibody