加入收藏
百奥莱博公司客服电话百奥莱博QQ百奥莱博QQ百奥莱博QQ
百奥莱博公司微信服务号

产品目录

所在位置:所有产品 > 抗体抗原 > 一抗 > HMGCS1抗体
HMGCS1抗体图片
产品货号:
Z17954
中文名称:
HMGCS1抗体
英文名称:
Anti-HMGCS1 Antibody
产品规格:
50μl|100μl|150μl
发货周期:
1~3天
产品价格:
询价
抗体名称Anti-HMGCS1 Antibody
指标别名HMG CoA synthase;HMGCS;HMGCS1
克隆性Polyclonal
检验物种human
应用范围WB,IHC,ICC/IF,FCM,ELISA
基因名称HMGCS1
抗体来源Rabbit
抗体类型IgG
免疫原E.coli-derived human HMGCS1 recombinant protein (Position:K251-H520).
实际分子量57KD
成分500μg/mL antibody with PBS,0.02% NaN3,1mg BSA and 50% glycerol.
纯化方式Immunogen affinity purified.
浓度500μg/mL
产品形态溶液
保存条件12 months from date of receipt,-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing.
背景资料In molecular biology,hydroxymethylglutaryl-CoA synthase or HMG-CoA synthase EC 2.3.3.10 is an enzyme which catalyzes the reaction in which acetyl-CoA condenses with acetoacetyl-CoA to form 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA).Cytoplasmic 3-hydroxy-3-methylglutaryl-CoA synthase (HMGCS1) catalyzes the first committed step of mevalonate pathway essential for cholesterol biosynthesis.HMGCS1 transcription is regulated by sterol levels.Studies showed that miR-223 reduces cholesterol biosynthesis by inhibiting HMGCS1 and methylsterol monooxygenase 1.In addition,activation of the EGFR family member ERBB4 induces the expression of SREBP-regulated genes (including HMGCS1) involved in cholesterol biosynthesis,suggesting a role of this enzyme in the metabolic re-programming in ERBB4-driven cancers.
Uniprot IDQ01581
推荐配套试剂Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot.
基因名全称3-hydroxy-3-methylglutaryl-CoA synthase 1
蛋白名全称Hydroxymethylglutaryl-CoA synthase,cytoplasmic
推荐稀释比
Western blot (WB) 1:500~2000
Immunohistochemistry (IHC) 1:50~400
Immunocytochemistry/Immunofluorescence (ICC/IF) 1:50~400
Flow cytometry (FCM) 1~3μg/1×106 cells
Enzyme linked immunosorbent assay (ELISA) 1:100~1000
(Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user.

相关搜索:HMGCS1抗体HMGCS1多抗Anti-HMGCS1 Antibody
首页 |  关于我们 |  联系我们 |  在线咨询 |  网站地图
北京百奥莱博科技有限公司 京ICP备14007103号-3