产品货号：
Z17947
中文名称：
HMGCR抗体
英文名称：
Anti-HMGCR Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-HMGCR Antibody |
| 指标别名 | HMG CoA reductase;HMGCR |
| 克隆性 | Polyclonal |
| 检验物种 | human |
| 应用范围 | WB,IHC,IF,FCM,ELISA |
| 基因名称 | HMGCR |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | E.coli-derived human HMGCR recombinant protein (Position:H268-V842). |
| 实际分子量 | 97KD |
| 成分 | 500μg/mL antibody with PBS,0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate,the product of the reaction catalyzed by reductase.Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor.Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver,which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol,an important determinant of atherosclerosis.Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
| Uniprot ID | P04035 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P). |
| 基因名全称 | 3-hydroxy-3-methylglutaryl-CoA reductase |
| 蛋白名全称 | 3-hydroxy-3-methylglutaryl-coenzyme A reductase |
| 推荐稀释比 | Western blot (WB) 1:500～2000 Immunohistochemistry in paraffin section (IHC) 1:50～400 Immunofluorescence (IF) 1:50～400 Flow cytometry (FCM) 1～3μg/1×106 cells ELISA 1:100～1000 (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user. |
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