产品货号：
Z17892
中文名称：
HSP70抗体
英文名称：
Anti-HSP70 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-HSP70 Antibody |
| 指标别名 | HSP70;HSP70 1;HSP70 1/HSP70 2;HSP70 1A;HSP70.1/HSP70.2;HSP70I;HSP72;HSPA1;HSPA1A;HSPA1B;HSP70;HSP70 1/HSP70 2;HSP70 1B;HSP70 2;HSPA1;HSPA1A;HSPA1B |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB,IHC,IHC-F,ICC/IF,FCM |
| 基因名称 | HSPA1A/HSPA1B |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthetic peptide corresponding to a sequence at the N-terminus of human Hsp70(13-31aa TTYSCVGVFQHGKVEIIAN),identical to the related rat and mouse sequence. |
| 实际分子量 | 70KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | The 70 kilodalton heat shock proteins(Hsp70s) are a family of ubiquitously expressed heat shock proteins.The Hsp70s are an important part of the cell's machinery for protein folding,and help to protect cells from stress.All of the Hsp70 proteins have three major functional domains:An N-terminal ATPase domain binds ATP(Adenosine triphosphate) and hydrolyzes it to ADP(Adenosine diphosphate);A substrate binding domain contains a groove with an affinity for neutral,hydrophobic amino acid residues;A C-terminal domain rich in alpha helical structure acts as a 'lid' for the substrate binding domain.By binding tightly to partially-synthesized peptide sequences(incomplete proteins),Hsp70 prevents them from aggregating and being rendered nonfunctional.And it also can act to protect cells from thermal or oxidative stress.Finally,Hsp70 seems to be able to participate in disposal of damaged or defective proteins.Interaction with CHIP(Carboxyl-terminus of Hsp70 Interacting Protein)–an E3 ubiquitin ligase–allows Hsp70 to pass proteins to the cell's ubiquitination and proteolysis pathways. |
| Uniprot ID | P0DMV8/P0DMV9 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P).*Blocking peptide可以联系我们购买。 |
| 基因名全称 | heat shock 70kDa protein 8 |
| 蛋白名全称 | Heat shock cognate 71kDa protein |
| 推荐稀释比 | Western blot(WB) 1:500～2000 Immunohistochemistry in paraffin section (IHC) 1:50～400 Immunohistochemistry in frozen section (IHC-F) 1:50～400 Immunocytochemistry/Immunofluorescence (ICC/IF) 1:50～400 Flow cytometry (FCM) 1～3μg/1×106 cells (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user. |
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