产品货号：
Z17275
中文名称：
GEMC1/GMNC抗体
英文名称：
Anti-GEMC1/GMNC Antibody
产品规格：
0.1mg
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-GEMC1/GMNC Antibody |
| 指标别名 | GEMC1,GEMC1,Geminin coiled-coil domain-containing protein 1 |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse |
| 应用范围 | ELISA,WB |
| 基因名称 | GMNC |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | GEMC1 antibody was raised against a 19 amino acid synthetic peptide near the center of human GEMC1.The immunogen is located within amino acids 130 - 180 of GEMC1. |
| 计算分子量 | 38kDa |
| 成分 | GEMC1 Antibody is supplied in PBS containing 0.02% sodium azide. |
| 纯化方式 | GEMC1 Antibody is affinity chromatography purified via peptide column. |
| 浓度 | 1mg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 4℃可保存3个月，-20℃可保存1年。 |
| 背景资料 | The Geminin coiled-coil domain-containing protein 1 (GEMC1) is a highly conserved protein that is required for chromosomal replication.GEMC1 contains a region similar to the coiled-coil domain of geminin,an essential vertebrate replication protein in which the coiled-coil domain is required for the function.GEMC1 binds to the checkpoint and replication factor TopBP1,allowing the binding of GEMC1 to chromatin during pre-replication complex formation.GEMC1 also directly interacts with replication factors Cdc45 and Cdk2-CyclinE and stimulates the initiation of DNA replication.Depletion of GEMC1 by siRNA in embryonic and somatic vertebrate cells prevents DNA replication due to impairment of Cdc45 loading onto chromatin,suggesting GEMC1 promotes initiation of DNA replication by mediating TopBP1 and Cdk2 dependent recruitment of Cdc45 onto replication origins. |
| Uniprot ID | A6NCL1 |
| 基因名全称 | Geminin coiled-coil domain-containing protein 1 |
| 蛋白名全称 | Geminin coiled-coil domain-containing protein 1 |
| 推荐稀释比 | GEMC1 antibody can be used for detection of GEMC1 by Western blot at 1μg/mL.Antibody validated:Western Blot in mouse samples.All other applications and species not yet tested. |
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