产品货号：
Z16989
中文名称：
Glypican 1/GPC1抗体
英文名称：
Anti-Glypican 1/GPC1 Antibody
产品规格：
100μg
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-Glypican 1/GPC1 Antibody |
| 指标别名 | glypican;Glypican 1;glypican1;GPC1 |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | ELISA,IHC,WB |
| 基因名称 | GPC1 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | Anti-Glypican-1 protein A purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to an internal region of human glypican-1 protein. |
| 成分 | 0.02M Potassium Phosphate,0.15M Sodium Chloride,pH7.2,0.01% (w/v) Sodium Azide |
| 纯化方式 | Anti-Glypican-1 was protein A purified from monospecific antiserum by immunoaffinity chromatography using protein A coupled to agarose beads.This antibody is specific for human glypican-1 protein.A BLAST analysis was used to suggest partial cross-reactivity with glypican from rat,mouse,Macaque,dog,cattle,and opossum sources based on 100 ～ 88% homology with the immunizing sequence.Cross-reactivity with glypican from other sources has not been determined. |
| 浓度 | 2.0mg/mL by UV absorbance at 280nm |
| 产品形态 | 溶液 |
| 保存条件 | Store vial at -20℃ prior to opening.Aliquot contents and freeze at -20℃ or below for extended storage.Avoid cycles of freezing and thawing.Centrifuge product if not completely clear after standing at room temperature.This product is stable for several weeks at 4℃ as an undiluted liquid.Dilute only prior to immediate use.Expiration date is one (1) year from date of opening. |
| 背景资料 | Glypican-1 antibody is suitable for Cancer,Immunology and Nuclear Signaling research.Glypican-1 (also known as GPC1 or FLJ38078) is a member of the glypican-related integral membrane proteoglycan family (GRIPS).This protein is a heparan sulfate proteoglycan which is composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains and are anchored to the cell surface via a covalent linkage to glycosylphosphatidlyinositol (GPI).Glypicans can modify cell signaling pathways and contribute to cellular proliferation and tissue growth.In humans,glypican-1 is over expressed in breast and brain cancers (gliomas).All glypicans contain an N-terminal signal peptide and a hydrophobic domain in their C-terminal region which is required for attachment of the GPI anchor.The amino acid sequences of the six vertebrate glypican family members vary from 17% to 63% identity.The location of 14 cysteine amino acids is conserved between the glypicans,suggesting the existence of a highly similar three-dimensional structure.Heparan sulfate glycosaminoglycan chains are attached at the 50 amino acids at the C-terminal end of the protein,near the anchor and the cell membrane.Glypican functions as coreceptor for a variety of growth factors.Glypican-1 has been shown to interact with SLIT2. |
| Uniprot ID | P35052 |
| 推荐稀释比 | ELISA:1:10,000 - 1:50,000 IHC:10μg/mL WB:1:500- 1:2,000 |
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