产品货号：
Z16930
中文名称：
过氧化物酶标记GDF15抗体
英文名称：
Anti-GDF15 Antibody Peroxidase Conjugated
产品规格：
100μg
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-GDF15 Antibody Peroxidase Conjugated |
| 指标别名 | GDF 15;GDF15;MIC 1;MIC1;NAG 1;NRG 1;NSAID activated gene 1 protein;NSAID regulated gene 1 protein;PDF;PLAB;Placental TGF beta;PTGFB |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse |
| 应用范围 | ELISA |
| 基因名称 | GDF15 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | Anti-NAG-1 (C-terminal specific) antibody was prepared by repeated immunizations with a synthetic peptide corresponding to a region near the carboxy terminal end of human NAG-1 protein.?A residue of cysteine was added to facilitate coupling to KLH. |
| 成分 | 0.02M Potassium Phosphate,0.15M Sodium Chloride,pH7.2,10mg/mL Bovine Serum Albumin (BSA) - Immunoglobulin and Protease free,0.01% (w/v) Gentamicin Sulfate.Do NOT add Sodium Azide! |
| 纯化方式 | Anti-NAG-1 (C-terminal specific) was affinity purified from monospecific antiserum by immunoaffinity chromatography.This antibody reacts with the C-terminus of endogenous NAG-1 protein from human and mouse tissues.A BLAST analysis suggests reactivity with NAG-1 from chimpanzee and macaque based on a 100% homology.Partial reactivity is expected against rat based on an 86% homology with the immunizing sequence.Cross-reactivity with NAG-1 from other sources has not been determined. |
| 浓度 | 1.07mg/mL by UV absorbance at 280nm |
| 产品形态 | Lyophilized |
| 保存条件 | Store vial at 4℃ prior to restoration.For extended storage aliquot contents and freeze at -20℃ or below.Avoid cycles of freezing and thawing.Centrifuge product if not completely clear after standing at room temperature.This product is stable for several weeks at 4℃ as an undiluted liquid.Dilute only prior to immediate use.?Expiration date is one (1) year from date of opening. |
| 背景资料 | Non-steroidal anti-inflammatory drug (NSAID) activated gene (NAG-1) is a member of the transforming growth factor-beta (TGF-beta) superfamily.NAG-1 is also known as Macrophage Inhibitory Cytokine-1 (MIC-1),Growth Differentiation Factor 15 (GDF15),Placental Bone Morphogenetic Protein (PLAB),or Prostate Derived Factor (PDF).NAG-1 is expressed in human placenta,prostate and colon.It possesses antitumorigenic and proapoptotic activities.NAG-1 expression is dramatically increased in inflammation,injury and malignancy.Increase of NAG-1 expression is a feature of many cancers including breast,colon,pancreas and prostate.In a number of studies,NAG-1 expression was increased by a number of NSAIDs.This increase in expression may correlate with the chemopreventive effect NSAIDs seem to have with certain cancers.NAG-1 expression is also induced by PPAR gamma ligands and by several dietary compounds such as conjugated linoleic acids (CLAs),naturally occurring fatty acids in ruminant food products,indoles,epicatechin gallate,and genistein.Induced expression of NAG-1 results in stimulation of apoptosis and inhibition of cell growth.Inhibition of NAG-1 induced expression by small interference RNA (siRNA) results in repression of induced apoptosis.NAG-1 expression is regulated by a numbers of transcription factors such as ERG-1 and Sp1.EGR-1 may be necessary for NSAID-induced NAG-1 expression.The study of expression of NAG-1 proteins,including variants,is important to define their potential role as serum biomarkers for cancer diagnosis,treatment monitoring,epidemiology study,and nutrition surveys. |
| Uniprot ID | Q99988 |
| 推荐稀释比 | ELISA:1:10,000-1:50,000 IHC:1:500～1:2,500 WB:1:1,000-1:5,000 |
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