产品货号：
Z16773
中文名称：
FBXO4抗体
英文名称：
Anti-FBXO4 Antibody
产品规格：
100μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-FBXO4 Antibody |
| 指标别名 | Anti-F-box only protein 4;Fbx4;FBXO4;F box protein 4;F box protein Fbx4;FBX4;FBXO 4;FLJ10141 |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse |
| 应用范围 | IF,WB |
| 基因名称 | FBXO4 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | This whole rabbit serum was prepared by repeated immunizations with a synthetic peptide derived from sequences unique to the N-terminus of FBX4 and conserved between the human and murine proteins (see link below for the full-length sequence of the mouse gene product). |
| 成分 | 0.02M Potassium Phosphate,0.15M Sodium Chloride,pH7.2,0.01% (w/v) Sodium Azide |
| 纯化方式 | This antiserum is directed against human and mouse FBX4.Reactivity against homologues from other sources is not known. |
| 浓度 | 85mg/mL by Refractometry |
| 产品形态 | 溶液 |
| 保存条件 | Store vial at -20℃ prior to opening.Aliquot contents and freeze at -20℃ or below for extended storage.Avoid cycles of freezing and thawing.Centrifuge product if not completely clear after standing at room temperature.This product is stable for several weeks at 4℃ as an undiluted liquid.Dilute only prior to immediate use.Expiration date is one (1) year from date of opening. |
| 背景资料 | Skp/Cullin/F-box (SCF) complexes are part of a large family of E3 ubiquitin ligases in which F-box proteins determine substrate specificity.Substrate selection by F-box proteins may also be aided by accessory cofactors.The F-box only protein 4,FBX4,interacts via its F-box with SKP1 and CUL1 to form SCFFBX4 ubiquitin ligase.The activity of the SCFFBX4 complex can be regulated by aB crystallin,a small heat shock protein which serves as a specificity cofactor for FBX4 dependent ubiquitination.FBX4 together with aB crystallin (SCFFBX4-aB crystallin) promotes the ubiquitination of cyclin D1 phosphorylated at Thr-286.In addition,the SCFFBX4-aB crystallin ubiquitin ligase has been implicated in the ubiquitination of unknown substrates in desmin-related myopathy.SCFFBX4,in the absence of aB crystallin,also ubiquitinates the telomeric protein PIN2/TRF1. |
| Uniprot ID | Q8CHQ0 |
| 推荐稀释比 | ELISA:1:5,000 - 1:25,000 WB:1:500 - 1:3000 |
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