产品货号：
Z16755
中文名称：
Fascin/FSCN1抗体
英文名称：
Anti-Fascin/FSCN1 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-Fascin/FSCN1 Antibody |
| 指标别名 | 55kDa actin bundling protein;FAN1;Fascin;Fascin 1;Fascin;FSCN1;HSN;p55;Singed like protein;SNL |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB |
| 基因名称 | FSCN1 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthetic peptide corresponding to a sequence at the N-terminus of human Fascin(97-113aa DDGRWSLQSEAHRRYFG),identical to the related rat and mouse sequences. |
| 计算分子量 | 55KD |
| 实际分子量 | 55KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | Fascin is a actin cross-linking protein.The Fascin gene contains 5 exons and spans 7kb.It is a 54-58 kilodalton monomeric actin filament bundling protein originally isolated from sea urchin egg but also found in Drosophila and vertebrates,including humans.Fascin(from the Latin for bundle) is spaced at 11 nanometre intervals along the filament.The bundles in cross section are seen to be hexagonally packed,and the longitudinal spacing is compatible with a model where fascin cross-links at alternating 4 and 5 actins.It is calcium insensitive and monomeric.Fascin binds beta-catenin,and colocalizes with it at the leading edges and borders of epithelial and endothelial cells.The role of Fascin in regulating cytoskeletal structures for the maintenance of cell adhesion,coordinating motility and invasion through interactions with signalling pathways is an active area of research especially from the cancer biology perspective.Abnormal fascin expression or function has been implicated in breast cancer,colon cancer,esophageal squamous cell carcinoma,gallbladder cancer and prostate cancer. |
| Uniprot ID | Q16658 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P).*Blocking peptide可以联系我们购买。 |
| 基因名全称 | fascin homolog 1,actin-bundling protein(Strongylocentrotus purpuratus) |
| 蛋白名全称 | Fascin |
| 推荐稀释比 | Western blot (WB) 1:500～2000 |
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