产品货号：
Z16640
中文名称：
GRB7抗体
英文名称：
Anti-GRB7 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-GRB7 Antibody |
| 指标别名 | B47;GRB7;GRB7 adapter protein |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB,IHC |
| 基因名称 | GRB7 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthetic peptide corresponding to a sequence in the middle region of human GRB7(176-192aa DSRFVFRKNFAKYELFK),different from the related rat and mouse sequences by one amino acid. |
| 实际分子量 | 60KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | GRB7,growth factor receptor-bound protein 7,is a protein which in humans is encoded by the GRB7 gene.The product of this gene belongs to a small family of adaptor proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules.This gene encodes a growth factor receptor-binding protein that interacts with epidermal growth factor receptor(EGFR) and ephrin receptors.The protein plays a role in the integrin signaling pathway and cell migration by binding with focal adhesion kinase(FAK).Alternative splicing results in multiple transcript variants encoding different isoforms,although the full-length natures of only two of the variants have been determined to date.GRB7 is an SH2-domain adaptor protein that binds to receptor tyrosine kinases and provides the intra-cellular direct link to the Ras proto-oncogene.Human GRB7 is located on the long arm of chromosome 17,next to the ERBB2(alias HER2/neu) proto-oncogene.These two genes are commonly co-amplified(present in excess copies) in breast cancers.GRB7 though to be involved in migration,is well known to be over-expressed in testicular germ cell tumors,esophageal cancers,and gastric cancers. |
| Uniprot ID | Q14451 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P).*Blocking peptide可以联系我们购买。 |
| 基因名全称 | growth factor receptor-bound protein 7 |
| 蛋白名全称 | Growth factor receptor-bound protein 7 |
| 推荐稀释比 | Western blot(WB) 1:500～2000 Immunohistochemistry in paraffin section (IHC) 1:50～400 (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user. |
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