产品货号：
Z16325
中文名称：
Emerin/EMD抗体
英文名称：
Anti-Emerin/EMD Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-Emerin/EMD Antibody |
| 指标别名 | EDMD;EMD;Emerin;LEMD5;STA |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB,IHC,IHC-F,IF,ICC/IF,FCM |
| 基因名称 | EMD |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthetic peptide corresponding to a sequence at the N-terminus of human Emerin (1-48aa MDNYADLSDTELTTLLRRYNIPHGPVVGSTRRLYEKKIFEYETQRRRL),different from the related mouse sequence by eight amino acids,and from the related rat sequence by nine amino acids. |
| 实际分子量 | 34KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | Emerin is a serine-rich nuclear membrane protein that in humans is encoded by the EMD gene.And this gene is mapped to Xq28.Emerin is a member of the nuclear lamina-associated protein family.It mediates membrane anchorage to the cytoskeleton.Emery–Dreifuss muscular dystrophy is an X-linked inherited degenerative myopathy resulting from mutation in the EMD (also known clinically as STA) gene.Emerin appears to be involved in mechanotransduction,as emerin-deficient mouse fibroblasts failed to transduce normal mechanosensitive gene expression responses to strain stimuli.In cardiac muscle,emerin is also found complexed to beta-catenin at adherens junctions of intercalated discs,and cardiomyocytes from hearts lacking emerin showed beta-catenin redistribution as well as perturbed intercalated disc architecture and myocyte shape.This interaction appears to be regulated by glycogen synthase kinase 3 beta. |
| Uniprot ID | P50402 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P).*Blocking peptide可以联系我们购买。 |
| 推荐稀释比 | Western blot(WB) 1:500～2000 Immunohistochemistry in paraffin section (IHC) 1:50～400 Immunohistochemistry in frozen section 1:50～400 Immunocytochemistry in fixed cells 1:50～400 Flow cytometry (FCM) 1～3μg/1×106 cells Immunocytochemistry/Immunofluorescence (ICC/IF) 1:50～400 Immunofluorescence (IF) 1:50～400 (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user. |
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