产品货号：
Z16199
中文名称：
FRMPD4/TMEM94抗体
英文名称：
Anti-FRMPD4/TMEM94 Antibody
产品规格：
0.1mg
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-FRMPD4/TMEM94 Antibody |
| 指标别名 | TMEM94,TMEM94,Uncharacterized protein KIAA0195,Transmembrane protein 94 |
| 克隆性 | Polyclonal |
| 检验物种 | human |
| 应用范围 | ELISA,WB,IHC,IF |
| 基因名称 | TMEM94 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | FRMPD4 antibody was raised against an 18 amino acid synthetic peptide from near the center of human FRMPD4.The immunogen is located within amino acids 620 - 670 of FRMPD4. |
| 计算分子量 | 151kDa |
| 成分 | FRMPD4 Antibody is supplied in PBS containing 0.02% sodium azide. |
| 纯化方式 | FRMPD4 Antibody is affinity chromatography purified via peptide column. |
| 浓度 | 1mg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 4℃可保存3个月，-20℃可保存1年。 |
| 背景资料 | The FERM and PDZ domain containing (FRMPD) protein family consists of four proteins that contain a FERM (Four-point-one,erzin,radixin,moesin) domain and at least one PDZ (PSD-95/Discs large/Zonula-occuldens-1) domain.FRMPD4,also known as Preso,also contains another protein interaction domain termed WW (domain with two conserved Trp residues) at its amino terminus.It was identified through a yeast two-hybrid screen using the PDZ domain of PSD-95 as bait and is highly expressed in multiple regions of the brain and is enriched in the postsynaptic density (PSD) fractions.Overexpression of FRMPD4 in cultured hippocampal neurons significantly increased the linear density of dendritic spines without changing their length and width;conversely,knockdown experiments using RNAi caused a decrease in spine density,indicating FRMPD4 positively regulates dendritic spine density but not morphology.The decreased level of FRMPD4 also resulted in reduced levels of excitatory synaptic transmission,suggesting that FRMPD4 is required for maintenance of excitatory synaptic transmission. |
| Uniprot ID | Q12767 |
| 基因名全称 | KIAA0195 |
| 蛋白名全称 | KIAA0195 |
| 推荐稀释比 | FRMPD4 antibody can be used for detection of FRMPD4 by Western blot at 1 ～ 2μg/mL.Antibody can also be used for immunohistochemistry starting at 5μg/mL.For immunofluorescence start at 20μg/mL.Antibody validated:Western Blot in human samples;Immunohistochemistry in human samples and Immunofluorescence in human samples.All other applications and species not yet tested. |
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