产品货号：
Z16081
中文名称：
FMR1抗体
英文名称：
Anti-FMR1 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-FMR1 Antibody |
| 指标别名 | FMR1;FMRP;fragile X mental retardation 1;FRAXA;POF;POF1;Protein FMR 1 |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB,IHC,ICC/IF |
| 基因名称 | FMR1 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthetic peptide corresponding to a sequence at the N-terminus of human FMRP (164-200aa ENYQLVILSINEVTSKRAHMLIDMHFRSLRTKLSLIM),different from the related mouse and rat sequences by one amino acid. |
| 实际分子量 | 71～73KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | FMR1 (fragile X mental retardation 1) is a human gene that codes for a protein°Called fragile X mentalretardation protein,or FMRP.This protein,most commonly found in the brain,is essential for normal°Cognitive development and female reproductive function.Mutations of this gene can lead to fragile X syndrome,mental retardation,premature ovarian failure,autism,Parkinson's disease,developmental delays and other cognitive deficits.The protein encoded by this gene binds RNA and is associated with polysomes.Additionally,the encoded protein may be involved in mRNA trafficking from the nucleus to the cytoplasm.A trinucleotide repeat (CGG) in the 5' UTR is normally found at 6～53 copies,but an expansion to 55-230 repeats is the cause of fragile X syndrome.Expansion of the trinucleotide repeat may also cause one form of premature ovarian failure (POF1).Multiple alternatively spliced transcript variants that encode different protein isoforms and which are located in different cellular locations have been described for this gene. |
| Uniprot ID | Q06787 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P).*Blocking peptide可以联系我们购买。 |
| 基因名全称 | fragile X mental retardation 1 |
| 蛋白名全称 | Synaptic functional regulator FMR1 |
| 推荐稀释比 | Western blot (WB) 1:500～2000 Immunohistochemistry in paraffin section (IHC) 1:50～400 Immunocytochemistry/Immunofluorescence (ICC/IF) 1:50～400 (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user. |
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