产品货号：
Z15820
中文名称：
DCC抗体
英文名称：
Anti-DCC Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-DCC Antibody |
| 指标别名 | Colorectal cancer suppressor;CRC18;CRCR1;DCC;IGDCC1;Netrin receptor DCC;Tumor suppressor protein DCC |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB,IHC |
| 基因名称 | DCC |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthetic peptide corresponding to a sequence at the N-terminus of human DCC(162-178aa EVIGEPMPTIHWQKNQQ),identical to the related mouse sequence,and different from the related rat sequence by one amino acid. |
| 实际分子量 | 180KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | DCC(Deleted IN Colorectal Carcinoma) also known as CRC18 or CRCR1.The DCC gene encodes a functional receptor for netrin and mediates axon outgrowth and the steering response.Heterozygous loss-of-function mutations in DCC can result in congenital mirror movements.Alterations in DCC occur frequently in colorectal cancer.Studying a YAC contig containing the entire DCC coding region,they showed that the DCC gene spans approximately 1.4 Mb.Vogelstein(1995) stated that the precise location of the DCC gene was though to be 18q21.3.DCC is a receptor or a component of a receptor that mediates the effects of netrin-1 on commissural axons,and they complement genetic evidence for interactions between DCC and netrin homologs in C.DCC protein could be detected in varying abundance in all specimens of normal colonic mucosa analyzed as well as in all specimens of adenomatous polyps,colorectal carcinoma and colorectal liver metastases.DCC may function as a tumor-suppressor protein by inducing apoptosis in settings in which ligand is unavailable(for example,during metastasis or tumor growth beyond local blood supply) through functional caspase cascades by a mechanism that requires cleavage of DCC at asp1290.Stein et al.(2001) concluded that DCC plays a central role in netrin signaling of axon growth and guidance independent of A2B receptor activation. |
| Uniprot ID | P43146 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P).*Blocking peptide可以联系我们购买。 |
| 基因名全称 | deleted in colorectal carcinoma |
| 蛋白名全称 | Netrin receptor DCC |
| 推荐稀释比 | Western blot(WB) 1:500～2000 Immunohistochemistry in paraffin section (IHC) 1:50～400 (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user. |
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