产品货号：
Z15628
中文名称：
EPHA4抗体
英文名称：
Anti-EPHA4 Antibody (Center)
产品规格：
80μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-EPHA4 Antibody (Center) |
| 指标别名 | EK8;EPH like kinase 8;EPH receptor A4;EPHA4;Ephrin type A receptor 4;HEK8;SEK;TYRO1;Tyrosine protein kinase TYRO1 |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse |
| 应用范围 | IHC,WB |
| 基因名称 | EPHA4 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | This EPHA4 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 383-417 amino acids from the Central region of human EPHA4. |
| 计算分子量 | 110kDa |
| 成分 | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. |
| 纯化方式 | This antibody is purified through a protein A column,followed by peptide affinity purification |
| 保存条件 | Maintain refrigerated at 2～8℃ for up to 2 weeks.For long term storage,store at -20℃ in small aliquots to prevent freeze-thaw cycles. |
| 背景资料 | Receptor tyrosine kinase which binds membrane-bound ephrin family ligands residing on adjacent cells,leading to contact-dependent bidirectional signaling into neighboring cells.The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling.Highly promiscuous,it has the unique property among Eph receptors to bind and to be physiologically activated by both GPI-anchored ephrin-A and transmembrane ephrin-B ligands including EFNA1 and EFNB3.Upon activation by ephrin ligands,modulates cell morphology and integrin-dependent cell adhesion through regulation of the Rac,Rap and Rho GTPases activity.Plays an important role in the development of the nervous system controlling different steps of axonal guidance including the establishment of the corticospinal projections.May also control the segregation of motor and sensory axons during neuromuscular circuit development.Beside its role in axonal guidance plays a role in synaptic plasticity.Activated by EFNA1 phosphorylates CDK5 at 'Tyr-15' which in turn phosphorylates NGEF regulating RHOA and dendritic spine morphogenesis.In the nervous system,plays also a role in repair after injury preventing axonal regeneration and in angiogenesis playing a role in central nervous system vascular formation.Additionally,its promiscuity makes it available to participate in a variety of cell-cell signaling regulating for instance the development of the thymic epithelium. |
| Uniprot ID | P54764 |
相关搜索：EPHA4抗体，EPHA4(Center)多抗，Anti-EPHA4 Antibody (Center)