产品货号：
Z15165
中文名称：
DNA Polymerase Beta/POLB抗体
英文名称：
Anti-DNA Polymerase Beta/POLB Antibody
产品规格：
100μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-DNA Polymerase Beta/POLB Antibody |
| 指标别名 | DNA polymerase beta;POLB |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB |
| 基因名称 | POLB |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 计算分子量 | 38KD |
| 成分 | Liquid in PBS containing 50% glycerol,0.5% BSA and 0.02% sodium azide. |
| 纯化方式 | Immunogen affinity purified |
| 产品形态 | 溶液 |
| 保存条件 | -20℃可保存1年，短期保存或频繁使用请置于4℃，可保存一个月，避免反复冻融。 |
| 背景资料 | Polymerase (DNA directed),beta,also known as POLB,is an enzyme that,in humans,is encoded by the POLB gene.It is localized on 8p11.2.The protein encoded by this gene is a DNA polymerase involved in base excision and repair,also called gap-filling DNA synthesis.It is found that a truncated POLB is expressed in primary colorectal tumors and inhibits the normal repair function of wildtype POLB.The encoded protein,acting as a monomer,is normally found in the cytoplasm,but it translocates to the nucleus upon DNA damage.Several transcript variants of this gene exist,but the full-length nature of only one has been described to date.Additionally,human POLB forms a complex with and is methylated by PRMT6.In vitro,methylated POLB possesses significantly higher DNA polymerase activity when compared to that of unmodified enzyme.The increase in DNA polymerase activity upon methylation is due to the enhanced DNA binding and processivity of POLB. |
| Uniprot ID | P06746 |
| 基因名全称 | DNA polymerase beta |
| 推荐稀释比 | WB,1:500～1:2000 |
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