产品货号：
Z15087
中文名称：
Cyclin D3/CCND3抗体
英文名称：
Anti-Cyclin D3/CCND3 Antibody
产品规格：
100μg
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-Cyclin D3/CCND3 Antibody |
| 指标别名 | CCND3;cyclin D;Cyclin D3;G1/S specific cyclin D3 |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse |
| 应用范围 | ELISA,FCM,IHC,IP |
| 基因名称 | CCND3 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to the C-terminal domain of mouse Cyclin D3 protein. |
| 成分 | 0.02M Potassium Phosphate,0.15M Sodium Chloride,pH7.2,0.01% (w/v) Sodium Azide |
| 纯化方式 | Cyclin D3 affinity-purified antibody is directed against Cyclin D3 protein.The product was affinity purified from monospecific antiserum by immunoaffinity purification.A BLAST analysis was used to suggest reactivity with this protein from mouse,human,and bovine sources based on 100% homology for the immunogen sequence.Cross-reactivity with other sources has not been determined.No reactivity was observed against Cyclin D2. |
| 浓度 | 1.0mg/mL by UV absorbance at 280nm |
| 产品形态 | 溶液 |
| 保存条件 | Store vial at -20℃ prior to opening.Aliquot contents and freeze at -20℃ or below for extended storage.Avoid cycles of freezing and thawing.Centrifuge product if not completely clear after standing at room temperature.This product is stable for several weeks at 4℃ as an undiluted liquid.Dilute only prior to immediate use.Expiration date is one (1) year from date of opening. |
| 背景资料 | Anti-Cyclin D3 antibody was designed,produced,and validated as part of the Joy Cappel Young Investigator Award (JCYIA).Cyclin D3 belongs to a highly conserved cyclin family,whose members are the ultimate recipients of oncogenic signals.Cyclin D3 is a key component of the cell cycle progression machinery and induces progression through the G1 phase of the cell cycle.Cyclin D3 is expressed in nearly all proliferating cells,and shows the most broad expression pattern of all three D-type (D1-D3) cyclins.Cyclin D3 is encoded from the 6p21 chromosome region and the protein is predominantly localized in the nucleus.Once induced,cyclin D3 binds and activates its associated cyclin-dependent kinases CDK4 and CDK6.Amplification of the cyclin D3 gene and overexpression of cyclin D3 protein is seen in several human cancers.A large number of human malignancies contain lesions in pathways impacting on cyclin D3.Abnormal expression of Cyclin D3 is believed to be a driving force in several human cancers.A possible role for cyclin D3 in the malignancies of the lymphoid system is suggested by the observations that cyclin D3 gene is rearranged in several neoplastic diseases such as diffuse large B cell lymphomas or multiple myelomas.Anti-Cyclin D3 is ideal for researchers interested in Cancer Research and Immunology research. |
| Uniprot ID | P30282 |
| 推荐稀释比 | ELISA:1:1000 - 1:5000 Flow Cytometry:4μg/mL IHC:4μg/mL IP:5μg/mL WB:1.0μg/mL |
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