产品货号：
Z15041
中文名称：
CYP27B1抗体
英文名称：
Anti-CYP27B1 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-CYP27B1 Antibody |
| 指标别名 | cytochrome P450 family 27 subfamily B member 1;CP2B;CYP1;CYP1alpha;CYP27B;P450c1;PDDR;VDD1;VDDR;VDDRI;VDR;CYP27B1 |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB,IHC |
| 基因名称 | CYP27B1 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthetic peptide corresponding to a sequence at the C-terminus of human CYP27B1 (475-508aa HFEVQPEPGAAPVRPKTRTVLVPERSINLQFLDR),different from the related mouse and rat sequences by six amino acids. |
| 实际分子量 | 57KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | CYP27B1 belongs to the cytochrome P450 superfamily of enzymes.The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol,steroids and other lipids.The protein encoded by this gene localizes to the inner mitochondrial membrane where it hydroxylates 25-hydroxyvitamin D3 at the 1alpha position.This reaction synthesizes 1alpha,25-dihydroxyvitamin D3,the active form of vitamin D3,which binds to the vitamin D receptor and regulates calcium metabolism.Thus this enzyme regulates the level of biologically active vitamin D and plays an important role in calcium homeostasis.Mutations in this gene can result in vitamin D-dependent rickets type I. |
| Uniprot ID | O15528 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P).*Blocking peptide可以联系我们购买。 |
| 基因名全称 | cytochrome P450,family 27,subfamily B,polypeptide 1 |
| 蛋白名全称 | 25-hydroxyvitamin D-1 alpha hydroxylase,mitochondrial |
| 推荐稀释比 | Western blot (WB) 1:500～2000 Immunohistochemistry in paraffin section (IHC) 1:50～400 (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user. |
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