产品货号：
Z14800
中文名称：
FGFR1 (Y766)抗体
英文名称：
Anti-FGFR1 (Y766) Antibody
产品规格：
50μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-FGFR1 (Y766) Antibody |
| 指标别名 | bFGF R 1;BFGFR;CD331;CEK;FGFBR;FGFR 1;FGFR1;FLG;FLT 2;FLT2;Fms like tyrosine kinase 2;HBGFR;KAL2;N SAM;OGD;Proto oncogene c Fgr |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | IHC,WB |
| 基因名称 | FGFR1 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | This FGFR (Y766) antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 741-770 amino acids from the human region of human FGFR (Y766). |
| 计算分子量 | 92kDa |
| 成分 | Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. |
| 纯化方式 | This antibody is purified through a protein A column,followed by peptide affinity purification |
| 保存条件 | Maintain refrigerated at 2～8℃ for up to 2 weeks.For long term storage,store at -20℃ in small aliquots to prevent freeze-thaw cycles. |
| 背景资料 | Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development,cell proliferation,differentiation and migration.Required for normal mesoderm patterning and correct axial organization during embryonic development,normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system.Phosphorylates PLCG1,FRS2,GAB1 and SHB.Ligand binding leads to the activation of several signaling cascades.Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate.Phosphorylation of FRS2 triggers recruitment of GRB2,GAB1,PIK3R1 and SOS1,and mediates activation of RAS,MAPK1/ERK2,MAPK3/ERK1 and the MAP kinase signaling pathway,as well as of the AKT1 signaling pathway.Promotes phosphorylation of SHC1,STAT1 and PTPN11/SHP2.In the nucleus,enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription.FGFR1 signaling is down-regulated by IL17RD/SEF,and by FGFR1 ubiquitination,internalization and degradation. |
| Uniprot ID | P11362 |
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