产品货号：
Z14760
中文名称：
ELA2/ELANE抗体
英文名称：
Anti-ELA2/ELANE Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-ELA2/ELANE Antibody |
| 指标别名 | Bone marrow serine protease;ELA2;ELANE;Elastase 2;elastase 2;neutrophil;GE;HLE;HNE;Human leukocyte elastase;Medullasin;NE;Neutrophil elastase;PMN E;PMN elastase |
| 克隆性 | Polyclonal |
| 检验物种 | mouse,rat |
| 应用范围 | WB,IHC |
| 基因名称 | ELANE |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | E.coli-derived mouse Elastase/ELANE/ELA2 recombinant protein (Position:S27-N265).Mouse Elastase/ELANE/ELA2 shares 92% amino acid (aa) sequence identity with rat Elastase/ELANE/ELA2. |
| 实际分子量 | 29KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | Neutrophil elastase is a serine protease of neutrophil and monocyte granules.Its key physiologic role is in innate host defense,but it can also participate in tissue remodeling and possesses secretagogue actions important to local inflammatory responses.Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin.Humans have six elastase genes which encode structurally similar proteins.The encoded preproprotein is proteolytically processed to generate the active protease.Following activation,this protease hydrolyzes proteins within specialized neutrophil lysosomes,called azurophil granules,as well as proteins of the extracellular matrix.This protein also degrades the outer membrane protein A (OmpA) of E.coli as well as the virulence factors of such bacteria as Shigella,Salmonella and Yersinia.Mutations in this gene are associated with cyclic neutropenia and severe congenital neutropenia (SCN).This gene is present in a gene cluster on chromosome 19. |
| Uniprot ID | Q3UP87 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P).*Blocking peptide可以联系我们购买。 |
| 基因名全称 | elastase,neutrophil expressed |
| 蛋白名全称 | Neutrophil elastase |
| 推荐稀释比 | Western blot(WB) 1:500～2000 Immunohistochemistry in paraffin section (IHC) 1:50～400 (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user. |
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