产品货号：
Z14747
中文名称：
EIF5A抗体
英文名称：
Anti-EIF5A Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-EIF5A Antibody |
| 指标别名 | eIF 4D;EIF 5A;eIF 5A 1;eIF 5A1;EIF5A;EIF5A1;eIF5AI;Rev binding factor |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB,IHC,ICC/IF,FCM,ELISA |
| 基因名称 | EIF5A |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | E.coli-derived human EIF5A recombinant protein (Position:R86-K154). |
| 实际分子量 | 18KD |
| 成分 | 500μg/mL antibody with PBS,0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | Eukaryotic translation initiation factor 5A-1 is a protein that in humans is encoded by the EIF5A gene.Eukaryotic initiation factor 5A (eIF5A) is an mRNA-binding protein that is involved in translation elongation and plays an important role in promoting translation of polyproline motifs.The eIF5A (eIF5A1) and eIF5A2 genes encode the two vertebrate eIF5A isoforms.While eIF5A1 is expressed constitutively in all tissues,eIF5A2 is mainly expressed in gonads.eIF5A and eIF5A2 are the only identified proteins that contain the distinctive amino acid hypusine,which is generated posttranslationally from lysine through a highly conserved polyamine metabolism pathway.eIF5A function and hypusine modification are both essential for cell proliferation,as knock down of eIF5A expression or blocking eIF5A hypusine modification suppresses cancer cell proliferation.Interestingly,eIF5A is an identified component of a tumor suppressor network of the polyamine-hypusine axis.Co-suppression of both eIF5A and adenosylmethionine decarboxylase 1 (AMD1) promotes lymphomagenesis in mice,while heterozygous deletions of the corresponding AMD1 and eIF5A genes often occur together in human lymphomas. |
| Uniprot ID | P63241 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP C onjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P) and ICC. |
| 基因名全称 | eukaryotic translation initiation factor 5A |
| 蛋白名全称 | Eukaryotic translation initiation factor 5A-1 |
| 推荐稀释比 | Western blot (WB) 1:500～2000 Immunohistochemistry (IHC) 1:50～400 Immunocytochemistry/Immunofluorescence (ICC/IF) 1:50～400 Flow cytometry (FCM) 1～3μg/1×106 cells Enzyme linked immunosorbent assay (ELISA) 1:100～1000 (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user. |
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