产品货号：
Z14718
中文名称：
Dapper homolog 3/DACT3抗体
英文名称：
Anti-Dapper homolog 3/DACT3 Antibody
产品规格：
0.1mg
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-Dapper homolog 3/DACT3 Antibody |
| 指标别名 | RRR1,DAPPER3,RRR1,Dapper homolog 3,Antagonist of beta-catenin Dapper homolog 3 |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | ELISA,WB |
| 基因名称 | DACT3 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | Dact3 antibody was raised against a 17 amino acid synthetic peptide from near the amino terminus of human Dact3.The immunogen is located within amino acids 370 - 420 of Dact3. |
| 计算分子量 | 65kDa |
| 成分 | Dact3 Antibody is supplied in PBS containing 0.02% sodium azide. |
| 纯化方式 | Dact3 Antibody is affinity chromatography purified via peptide column. |
| 浓度 | 1mg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 4℃可保存3个月，-20℃可保存1年。 |
| 背景资料 | The Wnt signaling cascade is a conserved process in multicellular animals that plays important roles during development and can contribute to cancer and other diseases.Many members of this pathway are also expressed in the postnatal tissues such as brain.One such protein is Dact3,a member of the Dact protein family that was initially identified through binding to Disheveled (Dvl),a cytoplasmic protein essential to Wnt signaling.Dact3 is expressed in the ventral region of maturing somites,limb bud and branchial arch mesenchyme,embryonic CNS,and the adult brain.Recent evidence shows that Dact3 acts as a negative regulator Wnt/beta-catenin signaling that is repressed at the transcriptional level in colorectal cancer and this repression is associated with bivalent histone modifications.This repression can be reversed by pharmacological agents that targets both histone methylation and deacetylation,suggesting that Dact3 may be a potential target for therapeutic treatment of this cancer.At least three isoforms of Dact3 are known to exist. |
| Uniprot ID | Q96B18 |
| 基因名全称 | Dapper,antagonist of beta-catenin,homolog 3 (Xenopus laevis) |
| 蛋白名全称 | Dapper,antagonist of beta-catenin,homolog 3 (Xenopus laevis) |
| 推荐稀释比 | Dact3 antibody can be used for detection of Dact3 by Western blot at 1μg/mL.Antibody validated:Western Blot in rat samples.All other applications and species not yet tested. |
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