产品货号：
Z14001
中文名称：
COMT抗体
英文名称：
Anti-COMT Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-COMT Antibody |
| 指标别名 | catechol O methyltransferase;COMT |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB,IHC,IHC-F,ICC |
| 基因名称 | COMT |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | E.coli-derived human COMT recombinant protein (Position:G52-P271).Human COMT shares 81.9% and 81% amino acid (aa) sequence identity with mouse and rat COMT,respectively. |
| 实际分子量 | 24KD,28KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | Catechol O-methyltransferase,also called COMT,is one of the major mammalian enzymes involved in the metabolic degradation of catecholamines.This gene is mapped to 22q11.21.Catechol-O-methyltransferase catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines,including the neurotransmitters dopamine,epinephrine,and norepinephrine.This O-methylation results in one of the major degradative pathways of the catecholamine transmitters.In addition to its role in the metabolism of endogenous substances,COMT is important in the metabolism of catechol drugs used in the treatment of hypertension,asthma,and Parkinson disease.COMT is found in two forms in tissues,a soluble form (S-COMT) and a membrane-bound form (MB-COMT).The differences between S-COMT and MB-COMT reside within the N-termini. |
| Uniprot ID | P21964 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P).*Blocking peptide可以联系我们购买。 |
| 基因名全称 | catechol-O-methyltransferase |
| 蛋白名全称 | Catechol O-methyltransferase |
| 推荐稀释比 | Western blot(WB) 1:500～2000 Immunohistochemistry in paraffin section (IHC) 1:50～400 Immunohistochemistry in frozen section (IHC-F) 1:50～400 Immunocytochemistry in fixed cells (ICC) 1:50～400 (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user. |
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