产品货号：
Z13874
中文名称：
DFF40/CAD抗体
英文名称：
Anti-DFF40/CAD Antibody
产品规格：
0.1mg
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-DFF40/CAD Antibody |
| 指标别名 | DNA fragmentation factor subunit beta;3.-.-.-;Caspase-activated deoxyribonuclease;CAD;Caspase-activated DNase;DNA fragmentation factor 40kDa subunit;DFF-40;Dffb;Cad |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | ELISA,WB,ICC,IF |
| 基因名称 | DFFB |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | DFF40 antibody was raised against a peptide corresponding to 18 amino acids near the center of murine CAD.The immunogen is located within amino acids 130 - 180 of DFF40. |
| 计算分子量 | 39kDa |
| 成分 | DFF40 Antibody is supplied in PBS containing 0.02% sodium azide. |
| 纯化方式 | DFF40 Antibody is affinity chromatography purified via peptide column. |
| 浓度 | 1mg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 4℃可保存3个月，-20℃可保存1年。 |
| 背景资料 | Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands.Cell death signals are transduced by death domain containing adapter molecules and members of the caspase family of proteases.These death signals finally cause the degradation of chromosomal DNA by activated DNase.A mouse DNase that causes DNA fragmentation was identified recently and designated CAD (for caspase activated deoxyribonuclease).The human homologue of mouse CAD was more recently identified by three groups independently and termed CPAN,DFF40,and human CAD,respectively.DFF45/ICAD is the inhibitory protein of DFF40/CAD and forms complex with DFF40/CAD.Upon cleavage of DFF45/ICAD by activated caspase,DFF40/CAD is released and activated and eventually causes the degradation of DNA in the nuclei.Activation of DFF40/CAD,which causes DNA degradation,is the hallmark of apoptotic cell death. |
| Uniprot ID | O54788 |
| 基因名全称 | DNA fragmentation factor,beta subunit |
| 蛋白名全称 | DNA fragmentation factor,beta subunit |
| 推荐稀释比 | DFF40 antibody can be used for detection of DFF40 by Western blot 0.5μg/mL.A 40kDa band can be detected.Antibody can also be used for immunocytochemistry starting at 5μg/mL.For immunofluorescence start at 20μg/mL.Antibody validated:Western Blot in human samples;Immunocytochemistry in human samples and Immunofluorescence in human samples.All other applications and species not yet tested. |
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