产品货号：
Z13778
中文名称：
CTCF抗体
英文名称：
Anti-CTCF Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-CTCF Antibody |
| 指标别名 | 11 zinc finger protein;CCCTC binding factor;CTCF;CTCFL paralog;Transcriptional repressor CTCF |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB,IHC,ICC/IF |
| 基因名称 | CTCF |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | E.coli-derived human CTCF recombinant protein (Position:K521-R727).Human CTCF shares 94% and 93.1% amino acid (aa) sequence identity with mouse and rat CTCF,respectively. |
| 实际分子量 | 140KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | Transcriptional repressor CTCF also known as 11-zinc finger protein or CCCTC-binding factor is a transcription factor that in humans is encoded by the CTCF gene.This gene is a member of the BORIS + CTCF gene family and encodes a transcriptional regulator protein with 11 highly conserved zinc finger (ZF) domains.And this nuclear protein is able to use different combinations of the ZF domains to bind different DNA target sequences and proteins.Depending upon the context of the site,the protein can bind a histone acetyltransferase (HAT)-containing complex and function as a transcriptional activator or bind a histone deacetylase (HDAC)-containing complex and function as a transcriptional repressor.If the protein is bound to a transcriptional insulator element,it can block communication between enhancers and upstream promoters,thereby regulating imprinted expression.Mutations in this gene have been associated with invasive breast cancers,prostate cancers,and Wilms' tumors.Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
| Uniprot ID | P49711 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P).*Blocking peptide可以联系我们购买。 |
| 基因名全称 | CCCTC-binding factor (zinc finger protein) |
| 蛋白名全称 | Transcriptional repressor CTCF |
| 推荐稀释比 | Western blot(WB) 1:500～2000 Immunohistochemistry in paraffin section (IHC) 1:50～400 Immunocytochemistry/Immunofluorescence (ICC/IF) 1:50～400 (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user. |
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