产品货号：
Z13363
中文名称：
Claudin 1/CLDN1抗体
英文名称：
Anti-Claudin 1/CLDN1 Antibody
产品规格：
0.1mg
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-Claudin 1/CLDN1 Antibody |
| 指标别名 | CLDN1 |
| 克隆性 | Polyclonal |
| 检验物种 | human,rat |
| 应用范围 | ELISA,WB,ICC,IF |
| 基因名称 | CLDN1 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | Anti-CLDN1 antibody was raised against a peptide corresponding to 20 amino acids near the carboxy terminus of human CLDN1.The immunogen is located within the last 50 amino acids of CLDN1. |
| 计算分子量 | 23kDa |
| 成分 | CLDN1 Antibody is supplied in PBS containing 0.02% sodium azide. |
| 纯化方式 | CLDN1 Antibody is affinity chromatography purified via peptide column. |
| 浓度 | 1mg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 4℃可保存3个月，-20℃可保存1年。 |
| 背景资料 | Claudin1 (CLDN1),a member of the claudin family,is an integral membrane protein and a component of tight junction strands.Tight junctions are specialized regions of cell to cell contact consisting of networking strands that act as a molecular gasket for preventing the leakage of ions,water,etc.,between cells.They are abundant in luminal epithelial sheets where they maintain epithelial cell polarity.Different tissues exhibit different Claudin composition and CLDN1 expression is often cell type and tissue dependent.Loss of function mutations result in neonatal ichthyosis-sclerosing cholangitis syndrome.CLDN1 and CLDN2 were found to be overexpressed in colonal cancer tissues and may be useful as tumor markers and targets for the treatment of colorectal cancer.Characterization of Claudins expression in human tumors can be an additional diagnostic tool.Recent studies show that CLDN1 has gastric tumor suppressive activity and is a direct transcriptional target of RUNX3.Along with SCARB1,LDL-R,and the tetraspanin superfamily member CD81,CLDN1 has been reported to be an entry factor for the Hepatitis C virus. |
| Uniprot ID | O95832 |
| 基因名全称 | Claudin 1 |
| 蛋白名全称 | Claudin 1 |
| 推荐稀释比 | WB:1～2μg/mL;ICC:5μg/mL;IF:20μg/mL.Antibody validated:Western Blot in human and rat samples;Immunocytochemistry in human samples;Immunofluorescence in human samples.All other applications and species not yet tested. |
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