产品货号：
Z13361
中文名称：
CISH抗体
英文名称：
Anti-CISH Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-CISH Antibody |
| 指标别名 | cytokine inducible SH2 containing protein;BACTS2;CIS;CIS-1;G18;SOCS;CISH |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB,IHC,ICC |
| 基因名称 | CISH |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthetic peptide corresponding to a sequence at the C-terminus of human CISH(241-258aa LPLPRRMADYLRQYPFQL),identical to the related rat and mouse sequences. |
| 实际分子量 | 29KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | CISH(cytokine inducible SH2-containing protein),also called CIS,CIS-1,G18,SOCS,is an important negative regulator for inflammatory signaling and belongs to the suppressors of cytokine signaling(SOCS) family.CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling.CISH controls interleukin-2 signaling,and variations of CISH with certain SNPs are associated with susceptibility to bacteremia,tuberculosis and malaria.The human CISH gene is mapped to chromosome 3p21.3 by FISH.The mouse gene is tightly linked to the Gnai2 gene on chromosome 9,a region syntenic to human chromosome 3p21.CIS expression was upregulated by lipopolysaccharide(LPS) or Cryptosporidium parvum exposure,and this upregulation involved downregulation of MIR98 and LET7,which relieved MIR98- and LET7-mediated translational repression of CIS.Gain- and loss-of-function studies showed that CIS accelerated degradation of IKBA and enhanced NFKB activation in cholangiocytes in response to LPS stimulation or C parvum exposure. |
| Uniprot ID | Q9NSE2 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P).*Blocking peptide可以联系我们购买。 |
| 基因名全称 | cytokine inducible SH2-containing protein |
| 蛋白名全称 | Cytokine-inducible SH2-containing protein(CIS) |
| 推荐稀释比 | Western blot(WB) 1:500～2000 Immunohistochemistry in paraffin section (IHC) 1:50～400 Immunocytochemistry 1:50～400 (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user. |
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