产品货号：
Z13321
中文名称：
CENPA抗体
英文名称：
Anti-CENPA Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-CENPA Antibody |
| 指标别名 | CENP A;CENPA;Centromere autoantigen A;centromere protein A |
| 克隆性 | Polyclonal |
| 检验物种 | human,rat |
| 应用范围 | WB |
| 基因名称 | CENPA |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | E.coli-derived human CENPA recombinant protein (Position:M1-G140).Human CENPA shares 71.6% amino acid (aa) sequence identity with mouse CENPA. |
| 实际分子量 | 16KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | Centromeres are the differentiated chromosomal domains that specify the mitotic behavior of chromosomes.CENPA encodes a centromere protein which contains a histone H3 related histone fold domain that is required for targeting to the centromere.And CENPA is proposed to be a component of a modified nucleosome or nucleosome-like structure in which it replaces 1 or both copies of conventional histone H3 in the (H3-H4)2 tetrameric core of the nucleosome particle.Alternative splicing results in multiple transcript variants encoding distinct isoforms.In higher eukaryotes,the recruitment of CENP-A nucleosomes to existing centromeres is an epigenetic process,independent of the underlying DNA sequence.In S.pombe,de novo recruitment of the CENP-A to the centromere is believed to be controlled by "centromeric" heterochromatin surrounding the centromere,and by an RNAi mechanism.The RNAi is cut to form siRNA;this complexes with the protein Chp1,which then binds the centromeric heterochromatin.This helps recruit other proteins,ultimately resulting in a protein complex that forms cohesin between two sister chromatids at the centromeric heterochromatin.This cohesin is believed to be essential in replacing the centromere H3 with CENP-A.CENP-A is one of the epigenetic changes that is believed to distinguish centromeric DNA from other DNA.Once the CENP-A has been added,the centromere becomes self-propagating,and the surrounding heterochromatin/RNAi mechanism is no longer necessary. |
| Uniprot ID | P49450 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P).*Blocking peptide可以联系我们购买。 |
| 基因名全称 | centromere protein A |
| 蛋白名全称 | Histone H3-like centromeric protein A |
| 推荐稀释比 | Western blot(WB) 1:500～2000 |
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