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产品目录

CD45/PTPRC抗体图片
产品货号:
Z12855
中文名称:
CD45/PTPRC抗体
英文名称:
Anti-CD45/PTPRC Antibody
产品规格:
50μl|100μl|150μl
发货周期:
1~3天
产品价格:
询价
抗体名称Anti-CD45/PTPRC Antibody
指标别名B220;CD45;CD45R;GP180;L CA;LCA;Leukocyte common antigen;LY5;PTPRC;RPTPC;T200
克隆性Polyclonal
检验物种human
应用范围WB,IHC,IF,ICC
基因名称PTPRC
抗体来源Rabbit
抗体类型IgG
免疫原A synthetic peptide corresponding to a sequence at the C-terminus of human CD45(1209-1227aa MVSTFEQYQFLYDVIASTY).
实际分子量180~250KD
成分500μg/mL antibody with PBS,0.02% NaN3,1mg BSA and 50% glycerol.
纯化方式Immunogen affinity purified.
浓度500μg/mL
产品形态溶液
保存条件12 months from date of receipt,-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing.
背景资料CD45(Cluster of Differentiation 45),also known as PTPRC,LCA or CD45R,is an enzyme that,in humans,is encoded by the PTPRC gene.CD45 is a member of the protein tyrosine phosphatase(PTP) family.CD45 is a major high molecular mass leukocyte cell surface molecule which is also an integral membrane protein tyrosine phosphatase.The cytogenetic location of CD45 is 1q31.3-q32.1.CD45 is especially a prototype for transmembrane protein-tyrosine phosphatase(PTP).Targeted disruption of the CD45 gene leads to enhanced cytokine and interferon receptor-mediated activation of JAKs and STAT proteins.In vitro,CD45 directly dephosphorylates and binds to JAKs.Functionally,CD45 negatively regulates interleukin-3-mediated cellular proliferation,erythropoietin-dependent hematopoiesis,and antiviral responses in vitro and in vivo.CD45 has been best studied in T cells,where it determines T cell receptor signaling thresholds.CD45 is moved into or out of the immunological synapse(IS) membrane microdomain depending on the relative influence of interaction with the extracellular galectin lattice or the intracellular actin cytoskeleton.Galectin interaction can be finetuned by varying usage of the heavily Oglycosylated spliced regions and sialylation of Nlinked carbohydrates.
Uniprot IDP08575
推荐配套试剂Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P).*Blocking peptide可以联系我们购买。
基因名全称protein tyrosine phosphatase,receptor type,C
蛋白名全称Receptor-type tyrosine-protein phosphatase C
推荐稀释比
Western blot(WB) 1:500~2000
Immunohistochemistry in paraffin section (IHC) 1:50~400
Immunocytochemistry 1:50~400Immunofluorescence/
Immunofluorescence (IF) 1:50~400
(Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user.

相关搜索:CD45/PTPRC抗体CD45抗体PTPRC多抗Anti-CD45/PTPRC Antibody
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