产品货号：
Z12681
中文名称：
c-Cbl/CBL抗体
英文名称：
Anti-c-Cbl/CBL Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-c-Cbl/CBL Antibody |
| 指标别名 | C CBL;CBL;CBL2;c-Cbl;Proto oncogene c Cbl;RING finger protein 55;RNF55 |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB,IHC,ICC/IF,FCM |
| 基因名称 | CBL |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | E.coli-derived human CBL recombinant protein (Position:A556-T906).Human CBL shares 84% amino acid (aa) sequence identity with mouse CBL. |
| 实际分子量 | 120KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | CBL(Cbl proto-oncogene) is also known as C-CBL,RNF55,CBL2 and E3 ubiquitin protein ligase.CBL is mapped to chromosome 11q23.3-qter by molecular characterization of the breakpoints in 2 somatic cell hybrids.The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome.This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes(E2) to specific substrates.This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation.As such it functions as a negative regulator of many signal transduction pathways.This gene has been found to be mutated or translocated in many cancers including acute myeloid leukaemia.Mutations in this gene are also the cause of Noonan syndrome-like disorder. |
| Uniprot ID | P22681 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P).*Blocking peptide可以联系我们购买。 |
| 基因名全称 | Cbl proto-oncogene,E3 ubiquitin protein ligase |
| 蛋白名全称 | E3 ubiquitin-protein ligase CBL |
| 推荐稀释比 | Western blot(WB) 1:500～2000 Immunohistochemistry in paraffin section (IHC) 1:50～400 Immunocytochemistry/Immunofluorescence (ICC/IF) 1:50～400 Flow cytometry (FCM) 1～3μg/1×106 cells (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user. |
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