产品货号：
Z12560
中文名称：
BTK抗体
英文名称：
Anti-BTK Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-BTK Antibody |
| 指标别名 | AGMX1;AT;ATK;B cell progenitor kinase;BPK;Bruton tyrosine kinase;BTK;IMD1;PSCTK1;Tyrosine protein kinase BTK;XLA |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB,IHC |
| 基因名称 | BTK |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | E.coli-derived human BTK recombinant protein (Position:A2-P340).Human BTK shares 98% amino acid (aa) sequence identity with mouse BTK. |
| 实际分子量 | 76KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | BTK,also known as Bruton's tyrosine kinase,is an enzyme that in humans is encoded by the BTK gene.It is mapped to Xq22.1.BTK plays a crucial role in B cell maturation as well as mast cell activation through the high-affinity IgE receptor.BTK contains a PH domain that binds phosphatidylinositol (3,4,5)-trisphosphate (PIP3).PIP3 binding induces BTK to phosphorylate phospholipase C,which in turn hydrolyzes PIP2,a phosphatidylinositol,into two second messengers,inositol triphosphate (IP3) and diacylglycerol (DAG),which then go on to modulate the activity of downstream proteins during B-cell signalling.This gene also regulates both TLR9 activation and expression in B lymphocytes and is necessary for inhibitory cytokine expression. |
| Uniprot ID | Q06187 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P).*Blocking peptide可以联系我们购买。 |
| 基因名全称 | Bruton agammaglobulinemia tyrosine kinase |
| 蛋白名全称 | Tyrosine-protein kinase BTK |
| 推荐稀释比 | Western blot(WB) 1:500～2000 Immunohistochemistry in paraffin section (IHC) 1:50～400 (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user. |
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