产品货号：
Z12538
中文名称：
Caspase 8/CASP8 (p10)抗体
英文名称：
Anti-Caspase 8/CASP8 (p10) Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-Caspase 8/CASP8 (p10) Antibody |
| 指标别名 | Apoptotic protease Mch 5;Casp 8;CASP8;Caspase 8;Caspase 8/p18;Caspase 8/p43/p18;caspase8;FADD like ICE;FLICE;ICE like apoptotic protease 5;MCH5 |
| 克隆性 | Polyclonal |
| 检验物种 | human |
| 应用范围 | WB,IHC |
| 基因名称 | CASP8 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthetic peptide corresponding to a sequence at the C-terminus of human Caspase-8(P10)(458-473aa TILTEVNYEVSNKDDK). |
| 实际分子量 | 55KD |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | Caspase 8 is a caspase protein.It most likely acts upon caspase 3.This gene encodes a member of the cysteine-aspartic acid protease(caspase) family.The human CASP8 gene,whose product is also known as caspase 8 and FLICE,encodes an interleukin-1beta converting enzyme(ICE)-related cysteine protease that is activated by the engagement of several different death receptors.Caspase 8 is immediately recruited to the Fas receptor once it oligomerizes,and its protease activity is crucial for the apoptotic response generated by the resulting death-inducing signaling complex(DISC).This gene contains at least 11 exons spanning approximately 30kb on human chromosome band 2q33-34.This region of human chromosome 2 was previously reported as the location of the CASP10 gene,whose product is closely related to caspase 8.Caspase-8 deficiency in humans is compatible with normal development and shows that caspase-8 has a postnatal role in immune activation of naive lymphocytes. |
| Uniprot ID | Q14790 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P).*Blocking peptide可以联系我们购买。 |
| 基因名全称 | caspase 8,apoptosis-related cysteine peptidase |
| 蛋白名全称 | Caspase-8(CASP-8) |
| 推荐稀释比 | Western blot(WB) 1:500～2000 Immunohistochemistry in paraffin section (IHC) 1:50～400 (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user. |
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